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J Dent Res：芳香氨基酸对羟基磷灰石的作用

2017-12-02 lishiting MedSci原创

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来源于牙齿超结构及专有特质的仿生学灵感促进着我们牙齿的修复治疗和新材料的研发。然而，我们却从未注意到牙齿颜色的变化，对其起源更是无从了解。基于近来的研究结果，蛋白中的荧光团芳香氨基酸(AAAs)有可能是决定牙齿颜色的因素。在此，研究者合成了存在不同氨基酸(AAs; 牙齿蛋白基质的基本单元)的碳羟基磷灰石(HA; 牙齿的矿化阶段)作为牙齿的一个简易模型来探索AA水平的颜色起源。

来源于牙齿超结构及专有特质的仿生学灵感促进着我们牙齿的修复治疗和新材料的研发。然而，我们却从未注意到牙齿颜色的变化，对其起源更是无从了解。基于近来的研究结果，蛋白中的荧光团芳香氨基酸(AAAs)有可能是决定牙齿颜色的因素。在此，研究者合成了存在不同氨基酸(AAs； 牙齿蛋白基质的基本单元)的碳羟基磷灰石(HA； 牙齿的矿化阶段)作为牙齿的一个简易模型来探索AA水平的颜色起源。

在漂白治疗前后，对HA-AAs的荧光和颜色特质分析显示，只有合成的HA存在AAAs，并展现出荧光效应和颜色特质。另外，在HA-AAAs中增加AAA容量会线性增强荧光强度以及颜色深度。同样，在漂白后，在250和300 nm紫外线光谱下HA-AAAs的吸收明显减弱，荧光强度降低，并且HA-AAAs表现出明显的脱色。结果显示，AAAs有助于HA的荧光效应和颜色特质，并且过氧化氢可能通过氧化AAAs中的苯环漂白HA-AAAs。

结论：这些研究对于促进更高级的牙齿染色材料的合成以及加深我们对过氧化氢可能的漂白机制的理解均有重要意义。另外，研究对也表明了AAAs的重要性，并且可能为生物矿化和生物仿真的研究提供了新思路。

原始出处：

Guo YR， Yang X， et al. New Insights into Effects of Aromatic Amino Acids on Hydroxyapatite. J Dent Res. 2017 Nov 1：22034517741274. doi： 10.1177/0022034517741274.

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    2018-08-29 zhaohui6731

    #氨基酸#

    0

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    2017-12-04 lofter

    学习了感谢分享

    0

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    2017-12-04 爆笑小医

    #羟基磷灰石#

    0

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    2017-12-02 三生有幸9135

    学习一下谢谢分享

    0

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    2017-12-02 天涯183

    非常好的文章.学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1860842, encodeId=8e4618608422b, content=<a href='/topic/show?id=5e746403ed5' target=_blank style='color:#2F92EE;'>#氨基酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64037, encryptionId=5e746403ed5, topicName=氨基酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Aug 29 05:45:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266646, encodeId=7c60266646e8, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C20CB8E4EBB36F5B821651C710BCB491/100, createdBy=18de1715848, createdName=lofter, createdTime=Mon Dec 04 07:15:03 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622120, encodeId=8eaf16221202e, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Dec 04 01:45:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266232, encodeId=db38266232d4, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Dec 02 19:02:06 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266223, encodeId=4bbc26622322, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Dec 02 14:22:07 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266215, encodeId=3d7726621566, content=很好的学习材料.对临床和科研都有很大帮助作用.水滴石穿.不断积累., beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Dec 02 13:36:36 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266195, encodeId=562626619543, content=不错的分享.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210427/b594a756d77e4171b5313e531ef89b43/31c000a8a97d4872b698c80fb8a33369.jpg, createdBy=624b2152505, createdName=大叔默默路过, createdTime=Sat Dec 02 12:04:26 CST 2017, time=2017-12-02, status=1, ipAttribution=)]
    2017-12-02 李东泽

    很好的学习材料.对临床和科研都有很大帮助作用.水滴石穿.不断积累.

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1860842, encodeId=8e4618608422b, content=<a href='/topic/show?id=5e746403ed5' target=_blank style='color:#2F92EE;'>#氨基酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64037, encryptionId=5e746403ed5, topicName=氨基酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Aug 29 05:45:00 CST 2018, time=2018-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266646, encodeId=7c60266646e8, content=学习了感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C20CB8E4EBB36F5B821651C710BCB491/100, createdBy=18de1715848, createdName=lofter, createdTime=Mon Dec 04 07:15:03 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1622120, encodeId=8eaf16221202e, content=<a href='/topic/show?id=f41b8000867' target=_blank style='color:#2F92EE;'>#羟基磷灰石#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80008, encryptionId=f41b8000867, topicName=羟基磷灰石)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Dec 04 01:45:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266232, encodeId=db38266232d4, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Dec 02 19:02:06 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266223, encodeId=4bbc26622322, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sat Dec 02 14:22:07 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266215, encodeId=3d7726621566, content=很好的学习材料.对临床和科研都有很大帮助作用.水滴石穿.不断积累., beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Dec 02 13:36:36 CST 2017, time=2017-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=266195, encodeId=562626619543, content=不错的分享.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210427/b594a756d77e4171b5313e531ef89b43/31c000a8a97d4872b698c80fb8a33369.jpg, createdBy=624b2152505, createdName=大叔默默路过, createdTime=Sat Dec 02 12:04:26 CST 2017, time=2017-12-02, status=1, ipAttribution=)]
    2017-12-02 大叔默默路过

    不错的分享.谢谢

    0