NEJM:帕尼单抗相关的睫毛伸长-病例报道

2020-10-15 MedSci原创 MedSci原创

帕尼单抗诱导的睫毛伸长是睫毛毛囊中EGFR抑制的结果。如果发展为睫毛伸长,通常会在治疗的最初几个月中注意到,就像该患者一样。病情随着治疗的停止而缓解,通常需要对症治疗。

患者为一名患有转移性印戒阑尾癌的53岁妇女,因肠梗阻入院。八个月前,她开始接受表皮生长因子受体(EGFR)抑制剂帕尼单抗治疗癌症。

体格检查发现她的脸部伴有明显的毛发生长,或睫毛伸长(如图A和B所示)。帕尼单抗开始治疗后2个月就出现这种情况,因肠梗阻住院时患者接受了拍照。睫毛伸长和痤疮是EGFR抑制剂治疗所致的皮肤病学方面有据可查的副作用。

据认为,帕尼单抗诱导的睫毛伸长是睫毛毛囊中EGFR抑制的结果。如果发展为睫毛伸长,通常会在治疗的最初几个月中注意到,就像该患者一样。病情随着治疗的停止而缓解,通常需要对症治疗。

该患者经非手术治疗肠梗阻后出院,并继续使用帕尼单抗。6个月后,她死于癌症的恶性转移。

原始出处:

Amrita Goyal,et al.Trichomegaly Associated with Panitumumab.N Engl J Med 2020;https://www.nejm.org/doi/full/10.1056/NEJMicm2003622

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    2022-08-02 ms1000001850758085

    真厉害

    0

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    2020-11-10 1248b370m54暂无昵称

    学习!

    0

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    2020-10-15 Psycho.Dr Du

    EGFR本来就可以增长睫毛吧?好多睫毛增长液不就是?#EGFR#

    0

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    2020-10-15 rayms

    帕尼单抗诱导的睫毛伸长是睫毛毛囊中EGFR抑制的结果。

    0

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    2020-10-15 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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