Hepatology:胆道淤积性婴儿中,肝硬度检测评估可能有助于婴儿胆道闭锁的诊断

2018-08-31 MedSci MedSci原创

胆道淤积性婴儿中,LSM评估可能会有助于对BA的诊断。

研究背景:本研究旨在确认瞬时弹性成像(TE)在诊断胆道性婴儿胆道闭锁(BA)的效用,以及预测BA的结果准确性。

研究方法和结果:研究纳入直接胆红素水平为1毫克/分升的48例胆红素婴儿(9-87天)。肝脏硬度测定(LSM)是在胆石病治疗过程中进行的,15例受试者被诊断为BA。对36例受试者进行肝活检,采用METAVIR评估肝脏组织学。相比未患有婴儿胆道闭锁的婴儿,患有婴儿胆道闭锁的婴儿其肝脏硬度更高、METAVIR指数更高。受试特征曲线 (ROC)分析表明,胆汁郁积的婴儿,LSM>7.7 kPa很可能患有婴儿胆道闭锁( [OR] = 128; P < 0.001)。在肝门肠吻合术(HPE)后的LSM的早期测量与手术6个月后,血栓性血小板减少、脾肿大和食管静脉曲张发生有关。其中五例受试者正在等待或接受肝移植(LT),他们的LSM比其他BA受试者的LSM高得多((26.0 vs. 10.8 kPa; P = 0.006 )。Cox比例分析表明,与其他BA受试者相比,LSM >16 kPa的患者的肝移植需求明显高于其他BA受试者(危险比HR=10.16;P = 0.04)

研究结论:胆道淤积性婴儿中,LSM评估可能有助于BA的诊断。

原始出处

Wu JF, Lee CS, Lin WH, et al. Transient elastography is useful in diagnosing biliary atresia and predicting prognosis after hepatoportoenterostomy. Hepatology, 2018, 68(2), 616-624.

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    2018-09-02 gwc384
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    2018-09-01 蔬菜

    谢谢谢谢谢谢分享,学习了新知识

    0

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    2018-08-31 医者仁心5538

    学习了

    0