Rheumatology:超重的骨关节炎患者疼痛程度更严重

2014-07-09 Elizabeth(编译) 睿医资讯

新近一项研究提示,具有膝关节炎的超重和肥胖人群感受到的疼痛程度可能大于关节损伤程度相同但体重较轻的患者。 既往研究已指出,体重较重的人群,尤其女性,发生骨关节炎的可能性更大,且发生更为严重的骨关节炎(OA)的可能性也更大。新近的这项研究在此基础上进行了更进一步的研究,结果提示,体重指数(BMI)较大的患者与关节相关损伤量相同的正常体重者相比,其疼痛程度更高。 来自美国加利福尼亚圣何塞州立大学的

新近一项研究提示,具有膝关节炎的超重和肥胖人群感受到的疼痛程度可能大于关节损伤程度相同但体重较轻的患者。

既往研究已指出,体重较重的人群,尤其女性,发生骨关节炎的可能性更大,且发生更为严重的骨关节炎(OA)的可能性也更大。新近的这项研究在此基础上进行了更进一步的研究,结果提示,体重指数(BMI)较大的患者与关节相关损伤量相同的正常体重者相比,其疼痛程度更高。

来自美国加利福尼亚圣何塞州立大学的人类学家Elizabeth Weiss在接受路透健康采访时表示,她此项研究的主要目的是想要把BMI、OA严重程度和疼痛程度关联起来,试图找出导致疼痛的原因。Weiss的研究方向是过去人口的骨骼情况,她表示不论人们所处的地域和年代,骨关节炎在有史以来一直是常见疾病。她的研究假设是,如果数据资料显示BMI是膝关节OA疼痛的罪魁祸首,那么过去的人们所经受的疼痛程度应该较低,而对于医生来说,这意味着即使患者OA病情无改善,但降低BMI仍有助于减轻患者的疼痛。

Weiss研究了近5000名45-79岁间的个体健康档案。其中共计1390名受试者已确诊为膝关节OA,3284名受试者无此诊断但具有发病风险,还有122名即无OA诊断也无相应风险。Weiss分析了这些受试者的X线片,以明确患者关节炎的病情严重程度,并通过健康档案收集受试者的BMI和日常活动中疼痛情况信息。

分析结果发现BMI较高的患者,疼痛程度也更高,即使在对关节受损的严重程度校准后,结果依旧如此。按照严重程度对关节炎患者进行分类,在所有类别的患者中,肥胖患者的疼痛评分均大幅高于正常体重者,超重患者的评分则居于两者之间。

Weiss在6月17日在线发表于《风湿病(Rheumatology)》杂志的文章中表示,尽管骨关节炎是一种进行性疾病,且其对患者的影响是不可逆的,但减轻体重可能有助于减轻疾病相关的疼痛。减轻体重可开启一个健康的循环:体重减轻可缓解疼痛,进而使人们更可能进行更多的体育活动,使得体重进一步减轻。对于疼痛程度较高的个体而言,进行运动以减轻体重也许难以实施,Weiss建议这类人群可在开始进行运动前先尝试减轻体重。通过饮食改变减轻体重比通过运动减重更为简单,有时小改变可造就大不同。

原始出处

Weiss E.Knee osteoarthritis, body mass index and pain: data from the Osteoarthritis Initiative.Rheumatology (Oxford). 2014 Jun 17

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    2014-07-18 lisa438
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    2014-07-16 lvjinglong

    切入点很好!值得学习!

    0

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    2014-07-11 lmm397

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  为通过饮食促进骨骼健康带来希望   英国东安格利亚大学的一项最新研究显示,西兰花中含有的一种化合物有望对防止或延缓常见关节炎的恶化发挥关键性作用。   实验室研究显示,萝卜硫素可以延缓可能导致严重致残性骨关节炎的关节软骨损伤。研究人员发现在给小鼠喂食富含萝卜硫素的食物后,出现关节软骨损伤和骨关节炎的情况比对照组大幅降低。研究人员同时还对人类软骨细胞和牛软骨组织进行了研究。   萝卜硫