J Eur Acad Dermatol Venereol:不同显微外科手术治疗基底细胞癌后的复发率如何?

2022-09-15 MedSci原创 MedSci原创

对于高风险的基底细胞癌(BCCs),显微外科手术(MS)具有较高的组织保存率和低复发率。Mohs技术是最常用的技术,其他MS技术的使用有限。目前还没有设计研究来比较MS方法。近日,发表于J Eur A

对于高风险的基底细胞癌(BCCs),显微外科手术(MS)具有较高的组织保存率和低复发率。Mohs技术是最常用的技术,其他MS技术的使用有限。目前还没有设计研究来比较MS方法。近日,发表于J Eur Acad Dermatol Venereol的一项综述评估了不同MS技术的BCC复发率。

研究人员在PubMed、LILACS、EMBASE、SCOPUS、WEB OF SCIENCE、CINHAL和COCHRANE检索相关研究,直至2021年3月,进行了系统回顾和荟萃分析。纳入BCC患者和不同MS技术适应症的随机临床试验(RCTs)和观察性研究。研究选择和数据提取由三位同行评审员独立完成,使用Joanna Briggs研究所的工具进行偏倚风险评估也是如此。使用随机效应模型(Logit)评估集合估计值,并通过卡方检验(χ2)评估异质性。分析时使用了17.0版的Stata软件。

结果,共纳入了18项研究,包括2项RCTs和16项观察性研究。分析结果显示,总复发率为2%(95% CI,1.0-3.0%;χ2 = 46.2;P = 0.00;18项研究,10 424个BCCs)。在使用Mohs技术的研究中,复发率为3.0%(95%CI,1.0-5.0%;χ2=11.0;P=0.00;6项研究;1 582例BCCs),Munich技术为3.0%(95%CI,2.0-5.0%;χ2=0. 0;无异质性;3项研究;404个BCCs),Tubingen技术1%(95%CI,1.0-2.0%;χ2 = 12.1;P = 0.00;8项研究;8374个BCCs),Muffin技术0.0%(95%CI,0.0-6.0%;1项研究;64个BCCs)。

综上所述,该研究结果表明,MS技术之间的复发率很低,似乎是相似的。然而,本综述的设计和缺乏直接比较这些技术的主要研究,使得结果无法确定它们之间的优越性。

 

原始出处:

P N Lacerda, et al., Recurrence rate of basal cell carcinoma among different micrographic surgery techniques: systematic review with meta-analysis. J Eur Acad Dermatol Venereol. 2022 Aug;36(8):1178-1190. doi: 10.1111/jdv.18048.  

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Braz J Otorhinolaryngol:头颈部皮肤鳞状细胞癌和基底细胞癌的细胞动力学标志物

增殖标志物在肿瘤的生物学行为中起着重要作用。双子蛋白是一种已知的细胞周期和DNA复制的抑制剂,我们旨在研究头颈部皮肤基底细胞癌和鳞状细胞癌中的增殖标志物ki67、MCM2和双子蛋白。

JEADV:刮除术与冷冻手术治疗浅表性基底细胞癌的比较研究

基底细胞癌(BCC)是人类中最常见的肿瘤,本文研究比较刮除术和冷冻手术治疗sBCCs在一年后的总体临床清除率和伤口愈合时间方面的有效性。

这些面部色素性增生物一定要警惕!

今天我们来看看常见的癌前期增生物以及恶性增生物。

Exp Dermatol :类似黑色素瘤的基底细胞癌的皮肤镜特征

这项研究的目的是在选定的具有黑色素细胞特征的非典型非面部基底细胞癌队列中,与具有至少一种基底细胞癌特征的非典型非面部MMS进行比较,以确定皮肤镜特征,以制定有助于鉴别诊断的评分。