Eur Respir J:特发性肺动脉高压患者右心室不同步与运动能力分析!

2017-06-18 xing.T MedSci原创

由此可见,采用综合超声心动图的斑点追踪来源的RV收缩的异质性评估可以提高IPAH患者有氧运动能力的预测。

肺动脉高压(PAH)患者生存是由适应后负荷的右心室功能(RV)所决定。然而RV功能改变是如何对PAH患者运动能力的影响尚不清楚。

近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员纳入了104例年龄在52±14 岁的特发性肺动脉高压(IPAH)患者,这些患者接受了诊断右心导管术检查、综合超声心动图包括二维斑点追踪来进行RV收缩不同步评价以及心肺运动试验。研究人员进行了多变量分析以确定峰值吸氧量(峰值V O2)的独立预测因子。

研究人员仅对静息血流动力学变量进行第一次多变量分析,以确定心脏指数、右心房(RA)压力和肺动脉顺应性作为独立预测因子,其预测能力较低(r2=0.31,p<0.001)。第二次多元分析模型只考虑超声参数但没有右心室不同步评估,以确定右心室面积变化分数(FAC)和RA面积为独立的预测因子仍具有较低的预测能力(r2=0.35;P<0.001)。如果将右心室不同步增加到第二次模型中可以明显提高预测能力(r2=0.48;P<0.001)。在保存RVFAC的患者中进行重复的第三次多元分析证实RV不同步可以得到峰值V′O2最高的预测能力(r2=0.53;P=0.001)。

由此可见,采用综合超声心动图的斑点追踪来源的RV收缩的异质性评估可以提高IPAH患者有氧运动能力的预测。

原始出处:

Roberto Badagliacca,et al. Right ventricular dyssynchrony and exercise capacity in idiopathic pulmonary arterial hypertension. Eur Respir J. http://erj.ersjournals.com/content/49/6/1601419

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channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Jun 20 06:12:18 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212708, encodeId=d2b2212e08ed, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Mon Jun 19 11:25:44 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212685, encodeId=30ce2126854b, content=很好学习了感谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Mon Jun 19 09:49:44 CST 2017, time=2017-06-19, status=1, ipAttribution=)]
    2017-06-24 大爰

    学习了谢谢分享!!

    0

  6. 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  8. 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channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Jun 20 06:12:18 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212708, encodeId=d2b2212e08ed, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Mon Jun 19 11:25:44 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212685, encodeId=30ce2126854b, content=很好学习了感谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Mon Jun 19 09:49:44 CST 2017, time=2017-06-19, status=1, ipAttribution=)]
    2017-06-20 龙胆草

    学习谢谢分享

    0

  9. 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channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Jun 20 06:12:18 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212708, encodeId=d2b2212e08ed, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Mon Jun 19 11:25:44 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212685, encodeId=30ce2126854b, content=很好学习了感谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Mon Jun 19 09:49:44 CST 2017, time=2017-06-19, status=1, ipAttribution=)]
    2017-06-19 往日如昨

    学习了谢谢分享

    0

  10. 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channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Jun 20 06:12:18 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212708, encodeId=d2b2212e08ed, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Mon Jun 19 11:25:44 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212685, encodeId=30ce2126854b, content=很好学习了感谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Mon Jun 19 09:49:44 CST 2017, time=2017-06-19, status=1, ipAttribution=)]
    2017-06-19 zwjnj2

    很好学习了感谢梅斯

    0

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