Stroke:颈动脉内膜中层厚度与白质高信号相关!

2017-12-29 xing.T MedSci原创

由此可见,较大的cIMT与更大的脑白质损伤负担相关,且独立于人口学与传统的血管危险因素,尤其是在老年人和西班牙裔中,这些人群为卒中和认知能力下降的高风险人群。

脑白质高信号(WMH)已被证实与卒中、认知功能减退和老年痴呆症风险增加有关。WMH可以是小血管病变的表现,虽然总的导致WMH的多种微血管病理生理学机制尚不清楚。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,在一个多民族老年无脑卒中的以社区为基础的队列中,研究人员假设颈动脉内膜中层厚度(cIMT)-亚临床血管疾病的超声成像指标,与脑WMH之间的可能关系。

研究人员在以人群为基础的无脑卒中北曼哈顿研究来评估CIMT与WMH之间的关系。在调整社会人口统计学、生活方式和血管危险因素后,研究人员使用线性回归来评估cIMT连续性指标与定量WMH体积之间的关联。

在1229名参与者(平均年龄为71±9岁;60%为女性,15%为白人,18%为黑人;65%为拉美裔),平均cIMT为0.71±0.08mm,平均对数转换的WMH体积为0.36(四分位距为0.21-0.76)。在多变量模型中,较大的cIMT与更大的WMH体积显著相关 (cIMT每变化一SD对应的β=0.046; P=0.04)。年龄和种族/民族是显著的调整因素(年龄P=0.02,种族/种族P=0.04)。70岁或以上的(cIMT每变化一SD对应的β=0.088;P=0.01)和西班牙裔(cIMT每变化一SD对应的β=0.084;P=0.003)参与者cIMT与WMH体积相关。

由此可见,较大的cIMT与更大的脑白质损伤负担相关,且独立于人口学与传统的血管危险因素,尤其是在老年人和西班牙裔中,这些人群为卒中和认知能力下降的高风险人群。

原始出处:


David Della-Morte, et al. Carotid Intima-Media Thickness Is Associated With White Matter Hyperintensities The Northern Manhattan Study.Stroke. 2017. https://doi.org/10.1161/STROKEAHA.117.018943

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encryptionId=20101021e97e, topicName=高信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e4137, createdName=meichuangyi, createdTime=Sun Jul 29 22:24:00 CST 2018, time=2018-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276815, encodeId=ff0e2e681543, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Tue Jan 09 08:29:05 CST 2018, time=2018-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274699, encodeId=26812e4699ef, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Dec 30 11:06:03 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1765695, encodeId=30ce1e6569573, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Oct 20 15:24:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843492, encodeId=361d1843492d8, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Dec 30 11:06:03 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2018-01-09 大爰

    学习了谢谢分享!!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1765695, encodeId=30ce1e6569573, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Sat Oct 20 15:24:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843492, encodeId=361d1843492d8, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Dec 30 11:06:03 CST 2017, time=2017-12-30, status=1, ipAttribution=)]
    2018-01-02 大爰

    学习了谢谢分享!!

    0

  7. 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    2018-01-02 jyzxjiangqin

    颈动脉内膜中层厚度.

    0

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    2017-12-30 sunfeifeiyang

    学习

    0

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