Stroke:无症状颈内动脉闭塞患者发生同侧卒中的风险较低

2016-04-18 fsy 译 MedSci原创

该系统评价的目的是量化无症状颈内动脉闭塞(ACAO)患者发生同侧卒中的风险。来自加拿大西安大略大学的研究人员通过检索MEDLINE,EMBASE和研究书目,确定了在ACAO患者中发生同侧卒中风险的研究。研究的评估采用随机效应模型进行合并,并使用I2统计对异质性进行定量。主要成果是同侧卒中的年增长率。该研究共确定了十三项试验,包括718例ACAO患者,平均随访2.8年。同侧卒中的年发生率为1.3%(

该系统评价的目的是量化无症状颈内动脉闭塞(ACAO)患者发生同侧卒中的风险。

来自加拿大西安大略大学的研究人员通过检索MEDLINE,EMBASE和研究书目,确定了在ACAO患者中发生同侧卒中风险的研究。研究的评估采用随机效应模型进行合并,并使用I2统计对异质性进行定量。主要成果是同侧卒中的年增长率。

该研究共确定了十三项试验,包括718例ACAO患者,平均随访2.8年。同侧卒中的年发生率为1.3%(95%可信区间为0.4-2.1; I2=53%)。同侧短暂性脑缺血发作的年发生率为1.0%(95%可信区间为0.3-1.8; I2=40%)。死亡的年发生率明显较高,为7.7%(95%可信区间为4.3-11.2; I2=83%)。原发性结果可能偏差校正表明同侧卒中风险较低(每年0.3%; 95%的置信区间,-0.4至1.1)。

脑卒中在ACAO患者中是比较罕见的,但患者面临着较高的死亡率。这表明在ACAO患者中需要进行强化治疗。

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    2016-04-20 那夏花开

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