Diabetes Obes Metab:需要急救住院的2型糖尿病患者严重低血糖患病率分析!

2017-06-19 xing.T MedSci原创

这些研究结果证实需要ER援助的2型糖尿病患者严重低血糖主要发生在胰岛素和促分泌剂为基础的治疗患者,具有显著的医疗负担相关。抗糖尿病治疗应个体化,以尽量减少严重的医源性低血糖的风险。

近日,代谢内分泌疾病领域权威杂志Diabetes Obesity & Metabolism上发表了一篇研究文章,在这项研究中,研究人员分析了采用降糖药(AHA)治疗的2型糖尿病患者严重低血糖的患病率以及需要急救室(ER)援助的情况。这种分析也是由AHA治疗所完成的。

HIPOS-ER研究是一项横断面、观察性、多中心、全国性研究,该研究对具体的低血糖源数据进行了采集。

在研究期间,共有425706名住院患者在参与研究的医院的急诊室进行登记。2型糖尿病严重低血糖事件患病率为0.074%。238例患者被纳入研究,其中一半以上是以胰岛素为基础的治疗(55%)以及三分之一(31.5%)以口服促分泌为基础的治疗。61.2%的初级保健主要是糖尿病护理。年龄中位数为77.5岁,平均糖尿病病程为19年。缺少一餐或低碳水化合物饮食是最常见的低血糖诱因(55.9%),寻求紧急援助最常见的诱因是先兆晕厥(19.2%)和短暂性意识丧失(17.4%)。44.1%的患者住院治疗的中位时间为5.1 天。在促分泌剂治疗组患者较胰岛素治疗组患者更容易(70.7% vs. 29%;P<0.001)。九例患者死亡。

这些研究结果证实需要ER援助的2型糖尿病患者严重低血糖主要发生在胰岛素和促分泌剂为基础的治疗患者,具有显著的医疗负担相关。抗糖尿病治疗应个体化,以尽量减少严重的医源性低血糖的风险。

原始出处:

João Conceição,et al. Severe Hypoglycemia Among Patients With Type 2 Diabetes Requiring Emergency Hospital Admission: The HIPOS-ER Study. Diabetes Obesity & Metabolism.2017. http://onlinelibrary.wiley.com/doi/10.1111/dom.13030/full

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01:23:00 CST 2017, time=2017-06-21, status=1, ipAttribution=)]
  5. 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01:23:00 CST 2017, time=2017-06-21, status=1, ipAttribution=)]
    2017-12-26 一闲
  6. 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01:23:00 CST 2017, time=2017-06-21, status=1, ipAttribution=)]
    2018-03-02 guojianrong
  7. 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  8. 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