The BMJ :偏头痛怎么办? 多吃鱼脂、少吃植物油可以减轻偏头痛

2021-07-02 MedSci原创 MedSci原创

偏头痛是一种神经系统疾病,是导致慢性疼痛、失去工作时间和降低生活质量的最常见原因之一。全世界有超过400 万人患有慢性偏头痛(每月至少 15 天偏头痛),超过 90% 的患者在发作期间无法正常工作或发

偏头痛是一种神经系统疾病,是导致慢性疼痛、失去工作时间和降低生活质量的最常见原因之一。全世界有超过400 万人患有慢性偏头痛(每月至少 15 天偏头痛),超过 90% 的患者在发作期间无法正常工作或发挥功能,发作可能持续 4 小时到 3 天不等。18 至 44 岁的女性特别容易患偏头痛,估计有 18% 的美国女性受到影响。尽管偏头痛的治疗选择在过去十年有所改善,但尽管服用多种药物,许多患者仍继续经历严重的疼痛和残疾。

近期一项发表在The BMJ  新研究表明,与摄入更多植物性脂肪和油的参与者相比,富含鱼的饮食有助于减少偏头痛患者每月的头痛次数和疼痛强度。

 在该研究中共有182 名参与者参加88% 女性,平均年龄 38 岁每月有 5-20 天有偏头痛在为期 16 周的饮食干预中,参与者被随机分配到三个健康饮食计划之一。参与者都收到了包括鱼、蔬菜、鹰嘴豆泥、沙拉和早餐食品的餐包。一组接受含有高脂肪鱼或脂肪鱼油和降低亚油酸的膳食 n-3+低 n-6(H3-L6 饮食)。第二组接受含有高脂肪鱼和高亚油酸的膳食高 n-3(H3 饮食)。第三组接受高亚油酸和低脂肪鱼的膳食(对照饮食,以模拟美国平均摄入量。

CONSORT(试验报告的综合标准)图示

在干预期间,参与者监测他们的偏头痛天数、持续时间和强度,他们的头痛如何影响他们在工作、学校和社交生活中的运作能力,以及他们需要服用止痛药的频率。研究员探究在减少或不减少 n-6 亚油酸的情况下增加 n-3 脂肪酸的饮食干预是否可以并减少成人偏头痛的头痛。主要终点(第 16 周)是血液中的镇痛介质 17-羟基二十二碳六烯酸 (17-HDHA) 和头痛影响测试 (HIT-6)

亚油酸是一种多不饱和脂肪酸,通常在美国人的饮食中从玉米、大豆和其他类似的油以及一些坚果和种子中提取。

研究发现与对照组相比,低植物油和高鱼脂的饮食使每天总头痛时间、每天严重头痛时间和每月总头痛天数减少了 30% 到 40%。这组参与者的血液样本中与疼痛相关的血脂水平也较低。尽管头痛频率和疼痛有所减少,但与研究中的其他组相比,这些参与者报告的与偏头痛相关的整体生活质量仅略有改善。

第16周的主要和次要终点

“这项研究发现了有趣的证据,表明饮食改变有可能改善非常虚弱的慢性疼痛状况,如偏头痛,而没有常用药物的相关副作用,”NIA 科学主任、医学博士、医学博士 Luigi Ferrucci 说。“饮食的改变可以为数百万患有偏头痛的美国人提供一些缓解,”拉姆斯登说。“这进一步证明我们吃的食物会影响疼痛通路。”

 

参考文献Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: randomized controlled trial, The BMJ, DOI: 10.1136/bmj.n1448www.bmj.com/content/374/bmj.n1448

 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2037092, encodeId=b843203e092b1, content=<a href='/topic/show?id=92be62e594a' target=_blank style='color:#2F92EE;'>#植物油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62759, encryptionId=92be62e594a, topicName=植物油)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0361487, createdName=花花1366, createdTime=Wed Sep 01 10:39:04 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849281, encodeId=5d701849281b5, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon May 16 02:39:04 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995647, encodeId=4af299564e7a, content=学习了,尝试一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/d0158c14dd1c457b9368c1dbbad22679/c601c9d7e027460d9c8fdbd46e9184af.jpg, createdBy=9da64223678, createdName=lestard, createdTime=Sat Jul 03 10:21:29 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745380, encodeId=7b221e45380ca, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Thu Jan 20 03:39:04 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=979033, encodeId=bae29e90332c, content=十分有用的,好棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/b49b637ce90a455bb1e235f83924397b/5bf685e70c6643ba95249595009efb3d.jpg, createdBy=8ef85539728, createdName=DyralDeng, createdTime=Fri Jul 02 16:10:04 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=979032, encodeId=7fbc9e90323d, content=学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=01f55486436, createdName=ms2000001848315443, createdTime=Fri Jul 02 16:09:37 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=979016, encodeId=b4839e9016dd, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Fri Jul 02 15:24:35 CST 2021, time=2021-07-02, status=1, ipAttribution=)]
    2022-05-16 gaoxiaoe
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    2021-07-03 lestard

    学习了,尝试一下

    0

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    2022-01-20 xuyong535
  5. [GetPortalCommentsPageByObjectIdResponse(id=2037092, encodeId=b843203e092b1, content=<a href='/topic/show?id=92be62e594a' target=_blank style='color:#2F92EE;'>#植物油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62759, encryptionId=92be62e594a, topicName=植物油)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0361487, createdName=花花1366, createdTime=Wed Sep 01 10:39:04 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849281, encodeId=5d701849281b5, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon May 16 02:39:04 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995647, encodeId=4af299564e7a, content=学习了,尝试一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/d0158c14dd1c457b9368c1dbbad22679/c601c9d7e027460d9c8fdbd46e9184af.jpg, createdBy=9da64223678, createdName=lestard, createdTime=Sat Jul 03 10:21:29 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745380, encodeId=7b221e45380ca, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Thu Jan 20 03:39:04 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=979033, encodeId=bae29e90332c, content=十分有用的,好棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/b49b637ce90a455bb1e235f83924397b/5bf685e70c6643ba95249595009efb3d.jpg, createdBy=8ef85539728, createdName=DyralDeng, createdTime=Fri Jul 02 16:10:04 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=979032, encodeId=7fbc9e90323d, content=学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=01f55486436, createdName=ms2000001848315443, createdTime=Fri Jul 02 16:09:37 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=979016, encodeId=b4839e9016dd, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Fri Jul 02 15:24:35 CST 2021, time=2021-07-02, status=1, ipAttribution=)]
    2021-07-02 DyralDeng

    十分有用的,好棒

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2037092, encodeId=b843203e092b1, content=<a href='/topic/show?id=92be62e594a' target=_blank style='color:#2F92EE;'>#植物油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62759, encryptionId=92be62e594a, topicName=植物油)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0361487, createdName=花花1366, createdTime=Wed Sep 01 10:39:04 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849281, encodeId=5d701849281b5, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon May 16 02:39:04 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995647, encodeId=4af299564e7a, content=学习了,尝试一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/d0158c14dd1c457b9368c1dbbad22679/c601c9d7e027460d9c8fdbd46e9184af.jpg, createdBy=9da64223678, createdName=lestard, createdTime=Sat Jul 03 10:21:29 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745380, encodeId=7b221e45380ca, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Thu Jan 20 03:39:04 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=979033, encodeId=bae29e90332c, content=十分有用的,好棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/b49b637ce90a455bb1e235f83924397b/5bf685e70c6643ba95249595009efb3d.jpg, createdBy=8ef85539728, createdName=DyralDeng, createdTime=Fri Jul 02 16:10:04 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=979032, encodeId=7fbc9e90323d, content=学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=01f55486436, createdName=ms2000001848315443, createdTime=Fri Jul 02 16:09:37 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=979016, encodeId=b4839e9016dd, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Fri Jul 02 15:24:35 CST 2021, time=2021-07-02, status=1, ipAttribution=)]
    2021-07-02 ms2000001848315443

    学习了。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2037092, encodeId=b843203e092b1, content=<a href='/topic/show?id=92be62e594a' target=_blank style='color:#2F92EE;'>#植物油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62759, encryptionId=92be62e594a, topicName=植物油)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0361487, createdName=花花1366, createdTime=Wed Sep 01 10:39:04 CST 2021, time=2021-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849281, encodeId=5d701849281b5, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon May 16 02:39:04 CST 2022, time=2022-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=995647, encodeId=4af299564e7a, content=学习了,尝试一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/d0158c14dd1c457b9368c1dbbad22679/c601c9d7e027460d9c8fdbd46e9184af.jpg, createdBy=9da64223678, createdName=lestard, createdTime=Sat Jul 03 10:21:29 CST 2021, time=2021-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1745380, encodeId=7b221e45380ca, content=<a href='/topic/show?id=bdc262694bb' target=_blank style='color:#2F92EE;'>#植物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62694, encryptionId=bdc262694bb, topicName=植物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5e35527958, createdName=xuyong535, createdTime=Thu Jan 20 03:39:04 CST 2022, time=2022-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=979033, encodeId=bae29e90332c, content=十分有用的,好棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210702/b49b637ce90a455bb1e235f83924397b/5bf685e70c6643ba95249595009efb3d.jpg, createdBy=8ef85539728, createdName=DyralDeng, createdTime=Fri Jul 02 16:10:04 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=979032, encodeId=7fbc9e90323d, content=学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=01f55486436, createdName=ms2000001848315443, createdTime=Fri Jul 02 16:09:37 CST 2021, time=2021-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=979016, encodeId=b4839e9016dd, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Fri Jul 02 15:24:35 CST 2021, time=2021-07-02, status=1, ipAttribution=)]
    2021-07-02 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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