Diabetes Care:四种社区因素与2型糖尿病患者糖化血红蛋白水平纵向变化的关系!

2017-12-20 xing.T MedSci原创

由此可见,社区结构与糖化血红蛋白变化相关,并会减弱TI的效应。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究旨在评价与糖化血红蛋白(HbA1c)相关的社区因素。

研究人员确定了HbA1c≥7.5%(58mmol/mol)并且在随后90-270天内进行糖化血红蛋白检测的2型糖尿病患者。在调整了人口统计学、HbA1c、BMI和2型糖尿病诊断时间后,研究人员使用混合效应模型评估了强化治疗(TI)和社会结构(社区社会经济剥夺[CSD]、食物获取、健康资产和体育活动设施利用[四分位数])与6个月和24个月HbA1c变化之间是否相关。研究人员采用使用交叉乘积项评估了社区结构改变是否与TI糖化血红蛋白变化相关。

在15308例患者中,有69818次测量HbA1c升高。在6个月内,HbA1c的平均下降率在CSD(第三位四分位数与第一位四分位数相比)水平较高的乡镇减少了0.07%个百分点。在食品供应最好的乡镇(相比于最差的乡镇),HbA1c减少了0.10%。在第二和第三位四分位数的体育活动设施利用相比于第一四分位数的患者,HbA1c降低0.17-0.19%。在乡镇和CSD最糟糕城镇(与最佳的相比)以及健身资产最好的城镇(和最差的相比)TI与6个月HbA1c变化之间的关联较弱。在CSD最差的(于第三位四分位数相比)普查区域,TI与24个月的HbA1c变化之间的相关性较弱,在体育活动设施利用较好的区域(与最坏的区域相比),TI与24个月的HbA1c变化之间的相关性最强。

由此可见,社区结构与糖化血红蛋白变化相关,并会减弱TI的效应。

原始出处:

Annemarie G. Hirsch,et al. Associations of Four Community Factors With Longitudinal Change in Hemoglobin A1c Levels in Patients With Type 2 Diabetes.Diabetes Care 2017. https://doi.org/10.2337/dc17-1200

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    2018-08-04 一叶知秋
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href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Fri Dec 22 04:59:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395736, encodeId=200c1395e368c, content=<a href='/topic/show?id=7a89e4036eb' target=_blank style='color:#2F92EE;'>#社区#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74036, encryptionId=7a89e4036eb, topicName=社区)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96f62500201, createdName=12498e67m28暂无昵称, createdTime=Fri Dec 22 04:59:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474374, encodeId=1aac14e43744f, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Dec 22 04:59:00 CST 2017, time=2017-12-22, status=1, ipAttribution=)]
    2018-01-31 戒馋,懒,贪

    谢谢分享学习了

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474374, encodeId=1aac14e43744f, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Fri Dec 22 04:59:00 CST 2017, time=2017-12-22, status=1, ipAttribution=)]
    2018-01-21 戒馋,懒,贪

    谢谢分享学习了

    0

  6. 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    2017-12-31 戒馋,懒,贪

    谢谢分享学习了

    0

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