WJCO:前哨淋巴结活检技术可决定腋窝淋巴结的手术方式

2014-12-18 MedSci MedSci原创

  WJCO:前哨淋巴结活检技术可决定腋窝淋巴结的手术方式 过去的十年,随着医疗水平及公众健康意识的提高,乳腺癌患者的构成趋向于早期,乳腺外科从激进的广泛切除模式向保留乳腺模式转变,同样,乳腺外科对腋窝淋巴结的处理也从常规切除发展到现在的前哨淋巴结活检(SLNB),这样可使SLNB(-)患者免于切除腋窝淋巴结,甚至某些SLNB(+)也可避免切除腋窝淋巴结,这将颠覆传统的乳腺外科

过去的十年,随着医疗水平及公众健康意识的提高,乳腺癌患者的构成趋向于早期,乳腺外科从激进的广泛切除模式向保留乳腺模式转变,同样,乳腺外科对腋窝淋巴结的处理也从常规切除发展到现在的前哨淋巴结活检(SLNB),这样可使SLNB(-)患者免于切除腋窝淋巴结,甚至某些SLNB(+)也可避免切除腋窝淋巴结,这将颠覆传统的乳腺外科治疗。 前哨淋巴结是指乳腺肿瘤转移的第一个淋巴结,行SLNB后切除腋窝淋巴结的患者将会使不良事件(血肿、淋巴水肿、感觉异常、活动受限)减少6-30%,然而存在5-10%的假阴性率,但有经验的医学中心可减少至5%。对于有淋巴结肿大患者不宜行SLNB,选择超声引导下穿刺病理学更有助于发现淋巴结转移。 SLNB(-)时对腋窝淋巴结的处理:对患者长期随访发现,SLNB(-)患者不行腋窝淋巴结清扫患者局部复发比预期的要少(5年腋窝复发率0.5-1.5%),这也得益于放射治疗和系统治疗的应用。因此这一手术方式被广泛运用以预防腋窝淋巴结切除术后的并发症。 SLNB(+)时对腋窝淋巴结的处理:腋窝淋巴结清扫时SLNB(+)患者的标准治疗,但是大样本的荟萃分析显示40-60%患者仅仅有前哨

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    2015-08-05 lidong40
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    2014-12-20 smlt2008
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