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Diabetes Care:HbA1c筛查2型糖尿病风险

2012-08-29 高晓方 医学论坛网

HbA1c2型糖尿病β细胞功能
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　　 美国学者的一项研究表明，HbA1c分类处于糖尿病前期的超重/肥胖青少年出现相对于胰岛素敏感性的β细胞功能受损。在大规模流行病学观测和（或）干预研究中，HbA1c可用作评估2型糖尿病风险进展或好转的筛查工具。论文于2012年8月21日在线发表于《糖尿病护理》（Diabetes Care）杂志。 　　 此项研究共纳入160例糖尿病前期（HbA1c 5.7%～6.5%）和44例HbA1c正常（&

　　 美国学者的一项研究表明，HbA1c分类处于糖尿病前期的超重/肥胖青少年出现相对于胰岛素敏感性的β细胞功能受损。在大规模流行病学观测和（或）干预研究中，HbA1c可用作评估2型糖尿病风险进展或好转的筛查工具。论文于2012年8月21日在线发表于《糖尿病护理》（Diabetes Care）杂志。

　　 此项研究共纳入160例糖尿病前期（HbA1c 5.7%～6.5%）和44例HbA1c正常（<5.7%）的超重/肥胖青少年。通过正糖高胰岛素钳夹技术对比肝脏和外周胰岛素敏感性，通过高糖钳夹试验对比β细胞功能。以处置指数判定β细胞功能。

　　结果显示，与HbA1c正常者相比，糖尿病前期受试者的空腹血糖、胰岛素以及OGTT葡萄糖和胰岛素曲线下面积均显著升高，肝脏和外周胰岛素敏感性降低，相对于胰岛素敏感性β细胞功能降低。HbA1c正常和糖尿病前期受试者中分别有27%和41%伴有血糖代谢障碍。

　　链接：

　　HbA1c Diagnostic Categories and β-Cell Function Relative to Insulin Sensitivity in Overweight/Obese Adolescents



    

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    2013-04-11 ms5439512287675881

    #BET#

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    2013-01-08 木头人513

    #Diabetes#

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    2012-11-13 ms9608593228839890

    #DIA#

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    2013-05-05 Smile2680

    #HbA#

    0

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    2013-01-07 ms3994565386320060

    #2型糖尿病风险#

    0

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 　　两年前一项报告中，柯里(Currie)等人通过英国全科医学数据库获取了27965例口服多种降糖药及20005例初始口服降糖药随后胰岛素治疗的糖尿病患者信息，随访5年发现，死亡率最低的是平均糖化血红蛋白(HbA1c)7.5%的患者，HbA1c平均值高于或低于这个数值都与存活率低相关。特别是胰岛素治疗的患者，HbA1c10.5%或6.0%患者死亡率几乎是HbA1c7.5%患者的2倍。