BMC Musculoskelet Disord:维生素D缺乏或与腰背痛有关

2013-09-10 desperado-c dxy

腰背痛由于其高发生率,是一种重要的公共健康问题,可导致活动受限,并且许多病例需要手术治疗。女性腰背痛比男性更常见,而且主要在绝经后女性。绝经后女性维生素D缺乏的患病率高,并与骨量丢失、肌肉减少症、椎体骨折和炎症反应相关,而骨量丢失、肌肉减少症、椎体骨折和炎症反应可能与腰背痛有关。为了评估腰背痛与维生素D缺乏之间的关系,以及有和没有维生素D缺乏女性之间卧床不起天数、不能上班天数和日常活动受限的差异,

腰背痛由于其高发生率,是一种重要的公共健康问题,可导致活动受限,并且许多病例需要手术治疗。女性腰背痛比男性更常见,而且主要在绝经后女性。绝经后女性维生素D缺乏的患病率高,并与骨量丢失、肌肉减少症、椎体骨折和炎症反应相关,而骨量丢失、肌肉减少症、椎体骨折和炎症反应可能与腰背痛有关。为了评估腰背痛与维生素D缺乏之间的关系,以及有和没有维生素D缺乏女性之间卧床不起天数、不能上班天数和日常活动受限的差异,来自巴西CCBR临床与基础研究中心Paulo Gustavo Sampaio Lacativa教授及其团队进行了一项研究,该研究发现维生素D缺乏与腰背痛有关,严重时,进行日常活动困难。该研究结果在线发表在2013年6月12日的BMC Musculoskelet Disorders杂志上。

该研究回顾了一项低骨量绝经后女性多中心干预III期临床试验的基线数据。包括人口统计资料、25OHD测定、腰背痛Newitt/Cummings调查问卷,并通过X线评估识别椎体骨折。

该研究结果表明,包括了9354例参与者,但仅有9305例参与者完成所有的评估。参与者的年龄中位数为67岁(60-85岁),并且绝经年龄为49岁(18-72岁)。22.5%受试者发现维生素D缺乏,15.3%受试者有椎体骨折,67.5%受试者有腰背痛,并且14.8%受试者在之前6月减少他们的日常活动。维生素D缺乏受试者与没有维生素D缺乏受试者相比,报道更多的腰背痛、有更多的严重腰背痛病例、日常活动受限更高、并有更多的骨折;同时,Newitt/Cummings调查问卷中维生素D缺乏受试者进行日常活动更费力。

该研究发现,维生素D缺乏与腰背痛有关,严重时,进行日常活动困难。

原文阅读

E Silva AV, Lacativa PG, Russo LA, de Gregório LH, Pinheiro RA, Marinheiro LP.Association of back pain with hypovitaminosis d in postmenopausal women with low bone mass.BMC Musculoskelet Disord. 2013 Jun 12;14(1):184.

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    2013-12-06 cmsvly
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