Diabetes Care：VD补充剂能否预防或延缓糖尿病发生？

2014-12-25 煦颖编译医学论坛网

一些观察性研究表明维生素D可以降低2型糖尿病的发病风险，但是缺乏长期的试验数据。维生素D和2型糖尿病(D2d)研究是一项随机的临床研究，为验证补充维生素D和糖尿病高风险人群发展为2型糖尿病之间是否存在因果关系，并验证补充维生素D是否安全有效地降低高风险糖尿病人群发展为2型糖尿病分的风险。研究内容及设计发表在《糖尿病医疗》上。 D2d的设计来自国家糖尿病、消化系统病和肾病研究所(NIDDK

一些观察性研究表明维生素D可以降低2型糖尿病的发病风险，但是缺乏长期的试验数据。维生素D和2型糖尿病(D2d)研究是一项随机的临床研究，为验证补充维生素D和糖尿病高风险人群发展为2型糖尿病之间是否存在因果关系，并验证补充维生素D是否安全有效地降低高风险糖尿病人群发展为2型糖尿病分的风险。研究内容及设计发表在《糖尿病医疗》上。

D2d的设计来自国家糖尿病、消化系统病和肾病研究所(NIDDK，National Institute of Diabetes and Digestive and Kidney Diseases) U34项目资助。最终协议由D2D研究组、数据安全监察委员会(the data and safety monitoring board)和NIDDK批准。

关键的入组标准为年龄大于等于30岁，体重指数为24–42 kg/m2(亚裔美国人为22.5)，糖尿病的风险增加[定义为满足美国糖尿病协会制定的糖尿病前期的3个血糖标准中的2个：空腹血糖(FPG) 为100–125 mg/dL(5.5–6.9 mmol/L)，75g葡萄糖负荷后餐后2小时血糖值140–199mg/dL(7.7–11 mmol/L)，糖化血红蛋白值5.7–6.4%(39–46 mmol/mol)]，无甲状旁腺功能亢进症，肾结石或高钙血症。

D2d参与者被随机分为每日一次的维生素D3(胆骨化醇4000 IU)或安慰剂治疗，平均随访3年。主要终点是发生糖尿病的时间，采用研究中的标准实验室评估或D2d以外的诊断。招募在2013年底启动。

原始出处：

Pittas AG1, Dawson-Hughes B2, Sheehan PR3, Rosen CJ4, Ware JH5, Knowler WC6, Staten MA7; D2d Research Group.Rationale and design of the vitamin d and type 2 diabetes (d2d) study: a diabetes prevention trial.Diabetes Care. 2014 Dec;37(12):3227-34. doi: 10.2337/dc14-1005. Epub 2014 Sep 9.

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2015-05-11 ms9608593228839890

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2015-06-28 木头人513

#Diabetes#

40 0
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2015-06-08 ljjj1053

好好学习学习

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2015-04-11 x35042875

他们的研究数据表明增加肠道中肠促胰素分泌细胞的数目，有可能成为改善血糖代谢的新型治疗方案。

129 0
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2015-05-31 ms5439512287675881

#BET#

27 0

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