Pediatrics:增殖腺扁桃体切除术对阻塞性睡眠呼吸暂停儿童的认知影响

2016-07-31 MedSci MedSci原创

研究显示增殖腺扁桃体切除术(AT)对阻塞性睡眠呼吸暂停综合症 (OSAS)患儿认知功能的影响证据喜忧参半。此研究的主要目的是在儿童扁桃体切除术随机试验中调查AT对认知功能评分的影响。 5到9岁患有OSAS,无长期血氧饱和度下降的儿童被随机分配到有支持护理的严密观察组 (n = 227)或早期 AT (eAT, n = 226)组。在干预前和干预后7个月进行神经心理学测试。使用混合模型分析比较

研究显示增殖腺扁桃体切除术(AT)对阻塞性睡眠呼吸暂停综合症 (OSAS)患儿认知功能的影响证据喜忧参半。此研究的主要目的是在儿童扁桃体切除术随机试验中调查AT对认知功能评分的影响。

5到9岁患有OSAS,无长期血氧饱和度下降的儿童被随机分配到有支持护理的严密观察组 (n = 227)或早期 AT (eAT, n = 226)组。在干预前和干预后7个月进行神经心理学测试。使用混合模型分析比较两组随访期间的评分变化,使用回归分析检测eAT组评分变化与睡眠措施变化的关系。

两组间的中位检测评分都在平均值水平。 eAT组比观察组随访期间的评分显著提高(P < .05) 。这些差异仅在非语言推理,精细运动技能,选择性注意中有较小的影响。AT相关的对评分有影响的额外证据是,eAT 组评分提高与睡眠措施改善相关。

结论:在患有OSAS,无长期血氧饱和度下降的儿童中,AT对认知功能检测仅有较小的选择性的影响。儿童扁桃体切除术试验中探究的手术对睡眠,行为,生活质量的更大影响相关证据中,AT也许对逆转OSAS患儿的认知功能存在有限的益处,或者这些益处可能在更进一步的随访研究中显现出来。

原始出处:

Taylor HG1, Bowen SR2, Beebe DW3, Hodges E4,et al,Cognitive Effects of Adenotonsillectomy for Obstructive Sleep Apnea,Pediatrics. 2016 Jul 27. pii: e20154458. [Epub ahead of print]


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    2016-10-09 tomyang96
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  5. 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  6. 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encodeId=6ac41e261601e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Aug 08 16:04:00 CST 2016, time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130211, encodeId=74f71302115f, content=不错哦继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 18 15:22:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=113653, encodeId=88dc11365386, content=好文章,赞一个!深入探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Sep 08 13:17:00 CST 2016, time=2016-09-08, status=1, ipAttribution=)]
    2017-02-28 hbwxf
  7. 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encodeId=6ac41e261601e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Aug 08 16:04:00 CST 2016, time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130211, encodeId=74f71302115f, content=不错哦继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 18 15:22:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=113653, encodeId=88dc11365386, content=好文章,赞一个!深入探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Sep 08 13:17:00 CST 2016, time=2016-09-08, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1696676, encodeId=00ab16966e6a5, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Sun Oct 09 01:04:00 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722317, encodeId=680a1e223170e, content=<a href='/topic/show?id=b9d95429465' target=_blank style='color:#2F92EE;'>#扁桃体切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54294, encryptionId=b9d95429465, topicName=扁桃体切除)], attachment=null, authenticateStatus=null, createdAvatar=null, 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15:22:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=113653, encodeId=88dc11365386, content=好文章,赞一个!深入探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Sep 08 13:17:00 CST 2016, time=2016-09-08, status=1, ipAttribution=)]
    2016-08-08 feather89
  9. 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15:22:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=113653, encodeId=88dc11365386, content=好文章,赞一个!深入探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Sep 08 13:17:00 CST 2016, time=2016-09-08, status=1, ipAttribution=)]
    2016-09-18 1e10c84am36(暂无匿称)

    不错哦继续关注

    0

  10. 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encodeId=6ac41e261601e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Aug 08 16:04:00 CST 2016, time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130211, encodeId=74f71302115f, content=不错哦继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 18 15:22:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=113653, encodeId=88dc11365386, content=好文章,赞一个!深入探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Sep 08 13:17:00 CST 2016, time=2016-09-08, status=1, ipAttribution=)]
    2016-09-08 ylzr123

    好文章,赞一个!深入探究。

    0