JASN:缓解血尿改善IgA肾病患者的肾脏存活!

2017-06-14 xing.T MedSci原创

由此可见,缓解血尿可能对IgA肾病的预后具有较好的效应。

血尿是IgA肾病的主要症状,但其对疾病进展风险的影响尚不清楚。近日,肾脏病领域权威杂志Journal of the American Society of Nephrology上发表一篇研究文章,研究人员随访了112例IgA肾病患者,随访时间平均值±标准差为14±10.2年,在随访期间研究人员定期记录了临床和分析的危险因素(包括尿沉渣检查)。

根据时间平均的血尿程度大小,研究人员将患者分为持续性血尿者和阴性或轻微血尿者。研究人员还将患者按时间平均的尿蛋白水平(>0.75或≤0.75g/d)将患者进行分类。

研究人员发现持续性血尿患者发展成终末期肾病或肾功能下降50%的患者比例明显高于血尿阴性者(分别为30.4%和37% vs. 10.6%和15.2%,P=0.01)。多变量分析显示时间平均血尿、时间平均蛋白尿、基础肾功能和肾活检间质纤维化可以作为终末期肾病的独立预测因子。46%的患者血尿消失后,肾功能下降从每年的-6.45±14.66到-0.18±2.56ml/min/1.73m2(P=0.001)。时间平均的尿蛋白>0.75g/d的患者有显著较差的肾存活率,相比于那些时间平均尿蛋白≤0.75g/d的患者,但对时间平均的血尿进一步分类,随着时间的推移,只有那些时间平均尿蛋白>0.75g/d和持续性血尿患者有较差的肾生存率,相比于其他三组。

由此可见,缓解血尿可能对IgA肾病的预后具有较好的效应。

原始出处:

Angel M. Sevillano,et al.Remission of Hematuria Improves Renal Survival in IgA Nephropathy. JASN, 2017, http://jasn.asnjournals.org/content/early/2017/06/06/ASN.2017010108.abstract

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createdName=gostraight, createdTime=Fri Aug 25 21:14:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1952789, encodeId=794b1952e89a5, content=<a href='/topic/show?id=7e678269256' target=_blank style='color:#2F92EE;'>#肾脏存活#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82692, encryptionId=7e678269256, topicName=肾脏存活)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Fri Feb 09 16:14:00 CST 2018, time=2018-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213890, encodeId=5af821389004, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLIB9dUjnMaj2giah13aaa7HO9licfLEl3FsfpYglvpqR5iar2W75Ah5kxwYoKzOfI5Fa5MW6Lx0EB77/0, createdBy=bccd2064123, createdName=151****9631, createdTime=Thu Jun 22 11:29:12 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414598, encodeId=eb601414598cb, content=<a href='/topic/show?id=c83e94827d' target=_blank style='color:#2F92EE;'>#IgA肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9482, encryptionId=c83e94827d, topicName=IgA肾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7c3073380, createdName=huiwelcome, createdTime=Fri Jun 16 06:14:00 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446945, encodeId=a1141446945ec, content=<a href='/topic/show?id=259d8906e50' target=_blank 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    2018-09-04 小石榴

    非常有用的文章,谢谢

    0

  2. 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    2017-12-03 chenhongpeng
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style='color:#2F92EE;'>#血尿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89067, encryptionId=259d8906e50, topicName=血尿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jun 16 06:14:00 CST 2017, time=2017-06-16, status=1, ipAttribution=)]
    2017-10-17 1010782452_36067043

    学习了

    0

  4. 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style='color:#2F92EE;'>#血尿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89067, encryptionId=259d8906e50, topicName=血尿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jun 16 06:14:00 CST 2017, time=2017-06-16, status=1, ipAttribution=)]
  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLIB9dUjnMaj2giah13aaa7HO9licfLEl3FsfpYglvpqR5iar2W75Ah5kxwYoKzOfI5Fa5MW6Lx0EB77/0, createdBy=bccd2064123, createdName=151****9631, createdTime=Thu Jun 22 11:29:12 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414598, encodeId=eb601414598cb, content=<a href='/topic/show?id=c83e94827d' target=_blank style='color:#2F92EE;'>#IgA肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9482, encryptionId=c83e94827d, topicName=IgA肾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7c3073380, createdName=huiwelcome, createdTime=Fri Jun 16 06:14:00 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446945, encodeId=a1141446945ec, content=<a href='/topic/show?id=259d8906e50' target=_blank style='color:#2F92EE;'>#血尿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89067, encryptionId=259d8906e50, topicName=血尿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jun 16 06:14:00 CST 2017, time=2017-06-16, status=1, ipAttribution=)]
  6. 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style='color:#2F92EE;'>#血尿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89067, encryptionId=259d8906e50, topicName=血尿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jun 16 06:14:00 CST 2017, time=2017-06-16, status=1, ipAttribution=)]
  7. 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style='color:#2F92EE;'>#血尿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89067, encryptionId=259d8906e50, topicName=血尿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jun 16 06:14:00 CST 2017, time=2017-06-16, status=1, ipAttribution=)]
  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLIB9dUjnMaj2giah13aaa7HO9licfLEl3FsfpYglvpqR5iar2W75Ah5kxwYoKzOfI5Fa5MW6Lx0EB77/0, createdBy=bccd2064123, createdName=151****9631, createdTime=Thu Jun 22 11:29:12 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414598, encodeId=eb601414598cb, content=<a href='/topic/show?id=c83e94827d' target=_blank style='color:#2F92EE;'>#IgA肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9482, encryptionId=c83e94827d, topicName=IgA肾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7c3073380, createdName=huiwelcome, createdTime=Fri Jun 16 06:14:00 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1446945, encodeId=a1141446945ec, content=<a href='/topic/show?id=259d8906e50' target=_blank style='color:#2F92EE;'>#血尿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89067, encryptionId=259d8906e50, topicName=血尿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jun 16 06:14:00 CST 2017, time=2017-06-16, status=1, ipAttribution=)]
    2017-06-22 151****9631

    学习了

    0

  9. 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  10. 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style='color:#2F92EE;'>#血尿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89067, encryptionId=259d8906e50, topicName=血尿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Jun 16 06:14:00 CST 2017, time=2017-06-16, status=1, ipAttribution=)]
    2017-06-16 quxin068