J Hepatology: 妊娠期非酒精性脂肪肝与围产期不良结局相关

2020-09-12 MedSci原创 MedSci原创

根据相关研究调查,非酒精性脂肪肝疾病(NAFLD)的患病率在年轻人中呈上升趋势,且对育龄妇女具有潜在的不良影响。

背景与目标:

根据相关研究调查,非酒精性脂肪肝疾病(NAFLD)的患病率在年轻人中呈上升趋势,且对育龄妇女具有潜在的不良影响。妊娠期间NAFLD是否会给母亲或围产期妇女的健康造成更大的风险尚不清楚。因此,研究人员就对此展开了相关研究。

 

 

方法

研究人员使用美国国家住院患者样本的出院数据,评估了妊娠20周后孕妇NAFLD的发病情况,并将其与其他慢性肝病(CLD)或无CLD的孕妇的结局进行了比较。研究结果包括早产,产后出血,高血压并发症(先兆子痫,子痫和/或溶血,肝酶升高和低血小板综合征)以及孕产妇或胎儿死亡等情况,并通过线性回归测试时间趋势。通过对年龄,种族,多胎妊娠和妊娠前糖尿病,肥胖,血脂异常和高血压进行校正的逻辑回归分析结果。

 

 

结果

在18574225例怀孕病历中,有5640例患有NAFLD,而115210例患有其他非NAFLD CLD。NAFLD怀孕从2007年的10.5 / 每100000怀孕到2015年(28.9 / 100,000(p <0.001))增加了近两倍,与其他组相比,妊娠期间患有NAFLD的患者更容易发生妊娠糖尿病(8% VS 23%),高血压并发症(4% VS  16%),产后出血(5%VS  6%)。和早产(5% VS 9%),所有p 值均≤0.01。经校正分析,与无CLD相比,NAFLD与高血压并发症,早产,产后出血死亡相关。

 

 

结论

最后研究人员说道:在过去的十年中,怀孕期间NAFLD的患病率几乎增加了两倍,并且与高血压并发症,产后出血和早产独立相关。

 

 

原始出处:

Monika Sarkar. Et al. Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes.Journal of Hepatology.2020.

 

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    2021-04-30 MedSciZeng

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1676588, encodeId=5c9816e658813, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Feb 17 13:48:18 CST 2021, time=2021-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1980559, encodeId=e6a6198055999, content=<a href='/topic/show?id=099f9548ed7' target=_blank style='color:#2F92EE;'>#酒精性脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95487, encryptionId=099f9548ed7, topicName=酒精性脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1676588, encodeId=5c9816e658813, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Wed Feb 17 13:48:18 CST 2021, time=2021-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1980559, encodeId=e6a6198055999, content=<a href='/topic/show?id=099f9548ed7' target=_blank style='color:#2F92EE;'>#酒精性脂肪肝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95487, encryptionId=099f9548ed7, topicName=酒精性脂肪肝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=26a9200, 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    2020-09-14 gwc384
  7. 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    2020-09-12 ms3000000301976572

    .-.

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    2020-09-12 ms3000000204266967

    怀孕期脂肪肝的病理生理改变如何呢?

    0

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    2020-09-12 谢好

    T_T

    0

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Lancet:非酒精性脂肪性肝、非酒精性脂肪性肝炎以及肝纤维化的鉴别新机制

近期,《柳叶刀胃肠病学和肝病学》在线发表了一篇关于鉴别非酒精性脂肪肝患者与肝纤维化患者的评分研究。

AJG:粪便微生物菌群移植可以改善非酒精性脂肪肝患者小肠通透性异常

非酒精性脂肪肝(NAFLD)是一种与肥胖有关的疾病,其发病率逐年增加,被认为是代谢综合征的肝脏表现。有研究报道,肠道微生物组在人体新陈代谢和维持肠道屏障完整性中起重要作用。

Cell Death Dis:SREBP1c类泛素化是非酒精性脂肪肝的潜在治疗靶标

在发达国家和发展中国家,非酒精性脂肪性肝病(NAFLD)均是一种常见的疾病,而且还是包括非酒精性脂肪性肝炎、肝硬化和肝癌在内的更高级肝脏疾病的先兆;因此,对于该病的预防是目前的一个重要的临床目标。

JCEM:1型糖尿病患者非酒精性脂肪性肝病患病率

1型糖尿病患者NAFLD的患病率很高,并且高度依赖于所用的诊断方法和NAFLD定义。