Int J Stroke:通过高分辨率血管壁MRI发现颅内斑块增强预测卒中复发

2016-04-04 MedSci MedSci原创

颅内动脉粥样硬化和频繁的卒中复发相关。高分辨率血管壁磁共振可以提供关于动脉粥样硬化易损性的信息。研究目标:我们对有颅内动脉粥样硬化的病人实施高分辨率磁共振来判断管壁斑块的性质可以预测未来卒中的复发。研究方法:在2011年7月到2013年6月,有症状性颅内粥样硬化的急性卒中的 病人被前瞻性入组,并对其相关动脉进行3T高分辨率磁共振检查。斑块增强 可以从注射钆剂后T1的增强图像判断。急性事件

颅内动脉粥样硬化和频繁的卒中复发相关。高分辨率血管壁磁共振可以提供关于动脉粥样硬化易损性的信息。

研究目标:我们对有颅内动脉粥样硬化的病人实施高分辨率磁共振来判断管壁斑块的性质可以预测未来卒中的复发。

研究方法:在2011年7月到2013年6月,有症状性颅内粥样硬化的急性卒中的 病人被前瞻性入组,并对其相关动脉进行3T高分辨率磁共振检查。斑块增强 可以从注射钆剂后T1的增强图像判断。急性事件后卒中再发被进行监测,多元COX比例风险模型建立判断和未来卒中相关的因素。

研究结果:138个病人中位随访时间为18个月。有39位病人卒中再发。斑块强化在108个病人(78.3%)中发现,其中37位病人卒中再发。在30位没有斑块增强的卒中病人中,2位病人有卒中再发。 Kaplan-Meier曲线展现例在有斑块强化和无斑块强化的病人中无事件生存有显著差异 (年事件率: 30.3% vs.  6.8%, 对数秩检验, p = 0.004)。多元COX回归分析表明高分辨率磁共振上斑块强化和卒中复发独立相关(风险比: 7.42, 95% 可信区间: 1.74-31.75, p =  0.007)。

研究结论:高分辨率磁共振显示的颅内斑块增强与症状性颅内动脉粥样硬化 病人的卒中再发相关。

原始出处:

Kim JM1, Jung KH2, Sohn CH3,et al,Intracranial plaque enhancement from high resolution vessel wall magnetic resonance imaging predicts stroke recurrence. Int J Stroke. 2016 Feb;11(2):171-9. doi: 10.1177/1747493015609775.


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    2016-04-26 ycmayy
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    2017-03-16 lsndxfj
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    2016-04-09 小猫cathy

    学习啦

    0

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