JAHA:老年人心脏结构和功能与糖尿病相关的死亡或心力衰竭风险的关系

2022-03-08 MedSci原创 MedSci原创

在老年人的混血儿队列中,心脏结构和功能异常部分解释了与糖尿病相关的事件风险增加。

即使在考虑了已知的心血管危险因素后,糖尿病与心力衰竭(HF)和死亡率的风险增加相关。与血糖异常相关的心脏结构和功能异常是否足以解释升高的死亡或心力衰竭(HF)风险仍未明确。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员分析了参加社区动脉粥样硬化风险(ARIC)研究中第5次随访评估(2011-2013年)的6059名参与者(平均年龄为75±5岁;58%为女性;22%为黑人)。

参与者分为无糖尿病、糖尿病前期和糖尿病(根据病史和糖化血红蛋白值来确定)三大类。研究人员评估了糖尿病是否改变了心脏结构和功能的超声心动图指标与全因死亡或心衰住院复合结局之间的关联,然后,研究人员估计了与糖尿病相关的复合结局风险增加的程度,主要通过心脏结构和功能来解释。

33.5%的受试者患有糖尿病。1111人(18%)发生死亡或心衰,每100人每年有3.6人死亡。在考虑了临床混杂因素后,心脏结构和功能以及糖尿病状态的指标均与较差的预后显著相关。虽然糖尿病始终与较高的事件风险相关,但它并没有显著改变心脏异常与死亡或心衰风险之间的关联,除了具有较高事件相对风险的左心房容积较高的受试者外(交互作用的P<0.001)。心脏结构和功能指标占与糖尿病相关的死亡或心衰风险增加了16%。在分析没有患有心脏病的受试者时,研究人员观察到了类似的结果。

由此可见,在老年人的混血儿队列中,心脏结构和功能异常部分解释了与糖尿病相关的事件风险增加。

原始出处:

Riccardo M. Inciardi.et al.Cardiac Structure and Function and Diabetes‐Related Risk of Death or Heart Failure in Older Adults.JAHA.2022.https://www.ahajournals.org/doi/10.1161/JAHA.121.022308

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1820511, encodeId=55b51820511d4, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Mon Apr 18 01:45:16 CST 2022, time=2022-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1201910, encodeId=7ef81201910ca, content=非常有用<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23ed5696429, createdName=ms9000001952326767, createdTime=Sat Mar 12 09:12:33 CST 2022, time=2022-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268789, encodeId=bfcb1268e8945, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Mar 09 12:45:16 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616020, encodeId=5f4e161602002, content=<a href='/topic/show?id=120f516469e' target=_blank style='color:#2F92EE;'>#心脏结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51646, encryptionId=120f516469e, topicName=心脏结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41019719888, createdName=12498adam46暂无昵称, createdTime=Wed Mar 09 12:45:16 CST 2022, time=2022-03-09, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1820511, encodeId=55b51820511d4, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Mon Apr 18 01:45:16 CST 2022, time=2022-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1201910, encodeId=7ef81201910ca, content=非常有用<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23ed5696429, createdName=ms9000001952326767, createdTime=Sat Mar 12 09:12:33 CST 2022, time=2022-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268789, encodeId=bfcb1268e8945, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Mar 09 12:45:16 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616020, encodeId=5f4e161602002, content=<a href='/topic/show?id=120f516469e' target=_blank style='color:#2F92EE;'>#心脏结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51646, encryptionId=120f516469e, topicName=心脏结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41019719888, createdName=12498adam46暂无昵称, createdTime=Wed Mar 09 12:45:16 CST 2022, time=2022-03-09, status=1, ipAttribution=)]
    2022-03-12 ms9000001952326767

    非常有用#心血管#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1820511, encodeId=55b51820511d4, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Mon Apr 18 01:45:16 CST 2022, time=2022-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1201910, encodeId=7ef81201910ca, content=非常有用<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23ed5696429, createdName=ms9000001952326767, createdTime=Sat Mar 12 09:12:33 CST 2022, time=2022-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268789, encodeId=bfcb1268e8945, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Mar 09 12:45:16 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616020, encodeId=5f4e161602002, content=<a href='/topic/show?id=120f516469e' target=_blank style='color:#2F92EE;'>#心脏结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51646, encryptionId=120f516469e, topicName=心脏结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41019719888, createdName=12498adam46暂无昵称, createdTime=Wed Mar 09 12:45:16 CST 2022, time=2022-03-09, status=1, ipAttribution=)]
    2022-03-09 zhaohui6731
  4. [GetPortalCommentsPageByObjectIdResponse(id=1820511, encodeId=55b51820511d4, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Mon Apr 18 01:45:16 CST 2022, time=2022-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1201910, encodeId=7ef81201910ca, content=非常有用<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23ed5696429, createdName=ms9000001952326767, createdTime=Sat Mar 12 09:12:33 CST 2022, time=2022-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268789, encodeId=bfcb1268e8945, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Mar 09 12:45:16 CST 2022, time=2022-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616020, encodeId=5f4e161602002, content=<a href='/topic/show?id=120f516469e' target=_blank style='color:#2F92EE;'>#心脏结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51646, encryptionId=120f516469e, topicName=心脏结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d41019719888, createdName=12498adam46暂无昵称, createdTime=Wed Mar 09 12:45:16 CST 2022, time=2022-03-09, status=1, ipAttribution=)]

相关资讯

Lancet:放置心房分流器并不能减少心力衰竭事件发生率!

心房分流器的放置并没有减少心力衰竭事件的总发生率,也没有改善射血分数大于或等于40%的心力衰竭患者的健康状况

JAHA:绝经后妇女组胺H2受体拮抗剂与心力衰竭风险之间的关系

临床H2RA的使用与绝经后妇女的HF事件无关。未来的研究需要根据性别、HF严重程度或使用模式对H2RA暴露和HF风险的潜在影响进行评估。

超13万人荟萃分析:这个内科超常用的药物,用超过3年或大大增加癌症,特别是肺癌发生风险!

PLOS ONE:血管紧张素受体阻滞剂的癌症风险随着累积暴露的增加而增加:随机试验的Meta回归分析。

Eur J Heart Fail:高血浆GDF-15浓度心力衰竭患者相关的病理生理机制

患有HF和血浆较高GDF-15浓度患者的特征是炎症通路和与IGF-1调节和骨/组织重塑相关的通路显著激活。

J Cardiol:非瓣膜性心房颤动合并急性心力衰竭患者使用艾多沙班治疗的D-二聚体水平变化分析

研究数据表明NVAF合并AHF患者的D-二聚体水平可能升高,特别是在那些没有进行事先抗凝治疗的患者中。根据标签使用艾多沙班可有效降低D-二聚体水平。