Sci Rep:DPP4抑制剂对2型糖尿病患者的β细胞功能和胰岛素抵抗作用荟萃分析

2017-03-21 MedSci MedSci原创

2型糖尿病的主要发病机制是β细胞功能障碍和胰岛素抵抗。DPP4抑制剂能够提高内源性GLP-1和GIP的活性,促进胰岛β胞释放胰岛素,同时抑制胰岛α细胞分泌胰高血糖素。

DPP4抑制剂是一种新型的口服降糖药,目前DDP4抑制剂对胰岛β细胞的保护作用报道不一。近期发表在Sci Rep上的一篇荟萃分析,通过分析2糖尿病患者的胰岛β细胞功能自稳态模型(HOMA-B)或胰岛素抵抗指数(HOMA-IR),评估了DPP4抑制剂对β细胞功能和胰岛素抵抗的影响。

该荟萃分析搜集了截止到20161227日收录在PubMed, EmbaseCochrane Library databases这三大数据库中的52例相关临床随机对照研究。研究人员对每一个入组的临床试验都进行了加权均数差(WMDs)和95%可信区间(CIs)的计算,并通过随机效应模型整理这些数据。该荟萃分析结果显示,和安慰剂组相比,DPP4抑制剂作为单一药物治疗(WMD 9.15; 95% CI 7.48, 10.81)以及与其他药物联合使用(WMD 9.04; 95% CI 5.72, 12.37),均可显著提高胰岛β细胞功能(HOMA-B指数)。然而,不管是作为单一药物治疗还是与其他药物联合使用,DPP4抑制剂对胰岛素抵抗(HOMA-IR)均无改善作用。

该研究表明,在2糖尿病中,不管是作为单一药物治疗还是与其他药物联合使用,DPP4抑制剂可以改善胰岛β细胞功能,而对胰岛素抵抗并无显著作用。

原始出处:

Xiafei Lyu, Xiaolin Zhu, Bin Zhao, et al. Effects of dipeptidyl peptidase-4 inhibitors on beta-cell function and insulin resistance in type 2 diabetes: meta-analysis of randomized controlled trials. Scientific Reports 7, Article number: 44865 (2017) doi:10.1038/srep44865

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encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Tue Nov 21 10:55:00 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836906, encodeId=bb6118369066e, content=<a href='/topic/show?id=1f188e230c5' target=_blank style='color:#2F92EE;'>#荟萃分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87230, encryptionId=1f188e230c5, topicName=荟萃分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Wed Dec 27 13:55:00 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681334, encodeId=0b981681334a5, content=<a href='/topic/show?id=366b8e2299e' target=_blank style='color:#2F92EE;'>#荟萃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87229, encryptionId=366b8e2299e, topicName=荟萃)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c12d27855367, createdName=venlin, createdTime=Fri Oct 20 04:55:00 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=182230, encodeId=ec8518223099, content=不错,身体没有从胰岛素抵抗中调整恢复过来,仅仅是增加胰岛素有什么用呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/iaqwic5175nru3m7Aicf6ziaLBcrX18MLSemHA6HrL7nRaPAhWHG5ibib7RjbZ3eibjCNhlymmPYB2icaR6iaHaaX9HMp4w/0, createdBy=7e3c2040840, createdName=史云超, createdTime=Thu Mar 23 19:00:10 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383278, encodeId=773813832e86a, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Thu Mar 23 13:55:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474139, encodeId=47e114e4139c5, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu Mar 23 13:55:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586790, encodeId=428e1586e9017, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Thu Mar 23 13:55:00 CST 2017, time=2017-03-23, status=1, ipAttribution=)]
    2017-11-21 baoya
  5. 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  6. 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href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Thu Mar 23 13:55:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1474139, encodeId=47e114e4139c5, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu Mar 23 13:55:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586790, encodeId=428e1586e9017, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Thu Mar 23 13:55:00 CST 2017, time=2017-03-23, status=1, ipAttribution=)]
    2017-10-20 venlin
  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586790, encodeId=428e1586e9017, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Thu Mar 23 13:55:00 CST 2017, time=2017-03-23, status=1, ipAttribution=)]
    2017-03-23 史云超

    不错,身体没有从胰岛素抵抗中调整恢复过来,仅仅是增加胰岛素有什么用呢?

    0

  8. 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