Hypertension:长期血压变异性可增加新发慢性肾病风险

2015-06-11 小田 译 医学论坛网

无糖尿病个体的长期血压变异性是否与新发慢性肾病(CKD)风险有关,以及随访期间这种相关性是否独立于其他血压参数和代谢变化尚未知。日本学者对上述问题进行了探讨,结果表明,在那些无糖尿病的中老年一般人群中,3年间存在长期血压变异性与新发CKD风险有关,这种相关性独立于随访期间的平均和累积血压暴露以及代谢变化。相关论文近期在线发表于《高血压》(Hypert

糖尿病个体的长期血压变异性是否与新发慢性肾病(CKD)风险有关,以及随访期间这种相关性是否独立于其他血压参数和代谢变化尚未知。日本学者对上述问题进行了探讨,结果表明,在那些无糖尿病的中老年一般人群中,3年间存在长期血压变异性与新发CKD风险有关,这种相关性独立于随访期间的平均和累积血压暴露以及代谢变化。相关论文近期在线发表于《高血压》(Hypertension)杂志。

该研究纳入了48587例无糖尿病或CKD(估算肾小球滤过率<60 mL/min • 1.73 m2)、年龄在40岁至74岁的日本成人受试者(平均年龄61.7岁,男性占39%)。评估其基线和3年随访期间的血压水平。以标准差(SD)和3年期间4次随访的平均真实变异性定义为血压变异性。

结果显示,在随访期间,6.3%的人群进展为CKD。多变量校正逻辑回归模型分析显示,在校正临床特征和从0至3年时的平均血压后,收缩压(SBP)标准差(SDSBP,每5 mmHg)、舒张压标准差(SDDBP,每3 mmHg)、平均真实SBP变异性(每6 mmHg)和平均真实DBP变异性(每4 mmHg)分别增加1SD均与新发CKD有关[比值比(OR)分别为1.15、1.08、1.13和1.06,所有P值均<0.01]。在较正随访期间的附加代谢参数变化后,SDBP、平均真实血压变异性与CKD的相关性仍保持显著性(Ors为1.06–1.15;P值均<0.01)。对性别、抗高血压药的应用和高血压的敏感性分析显示出相似的结果。

原始出处:

Yuichiro Yano, Shouichi Fujimoto, Holly Kramer, Yuji Sato, Tsuneo Konta, Kunitoshi Iseki, Chiho Iseki, Toshiki Moriyama, Kunihiro Yamagata, Kazuhiko Tsuruya, Ichiei Narita, Masahide Kondo, Kenjiro Kimura, Koichi Asahi, Issei Kurahashi, Yasuo Ohashi, Tsuyoshi Watanabe.Long-Term Blood Pressure Variability, New-Onset Diabetes Mellitus, and New-Onset Chronic Kidney Disease in the Japanese General Population.Hypertension, May 18, 2015,66: 30-36.

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    2015-10-18 feather89
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    2015-07-29 sundong

    所以要平稳血压

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1725859, encodeId=b4991e25859f3, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Oct 18 14:03:00 CST 2015, time=2015-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038512, encodeId=619c20385129f, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Thu Jul 30 01:03:00 CST 2015, time=2015-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=33716, encodeId=142233e16ed, content=所以要平稳血压, beContent=null, objectType=article, channel=null, level=null, likeNumber=176, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Wed Jul 29 10:29:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32395, encodeId=270832395d7, content=血压变异性还是应该重视,不能大意, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=623f1625122, createdName=maple243, createdTime=Sun Jul 12 07:21:00 CST 2015, time=2015-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29541, encodeId=a8f12954106, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Fri Jun 26 12:39:00 CST 2015, time=2015-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=28994, encodeId=1e1528994f9, content=血压变异还是很有研究价值的, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2be01625436, createdName=fatalmelanie, createdTime=Thu Jun 25 16:31:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342322, encodeId=471b134232200, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sat Jun 13 00:03:00 CST 2015, time=2015-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501058, encodeId=a18f1501058f5, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sat Jun 13 00:03:00 CST 2015, time=2015-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27242, encodeId=2fbe2e2425e, content=高血压变异性的重视还不够。, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3b2c1627329, createdName=owlhealth, createdTime=Fri Jun 12 07:49:00 CST 2015, time=2015-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=27025, encodeId=80532e02587, content=高血压肾损害?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e5c31627260, createdName=Darcy2500, createdTime=Thu Jun 11 15:42:00 CST 2015, time=2015-06-11, status=1, ipAttribution=)]
    2015-07-12 maple243

    血压变异性还是应该重视,不能大意

    0

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    2015-06-26 huaxipanxing

    看看

    0

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    2015-06-25 fatalmelanie

    血压变异还是很有研究价值的

    0

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    2015-06-12 owlhealth

    高血压变异性的重视还不够。

    0

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    2015-06-11 Darcy2500

    高血压肾损害?

    0

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