Gastroenterology:艾滋患者易发食道癌和胃癌

2012-10-10 Gastroenterology Gastroenterology

  根据最近发表在Gastroenterology杂志(即美国胃肠病协会的官方杂志)的一项研究结果指出,艾滋病患者患食管癌、胃癌及非霍奇金淋巴瘤的危险性增加。   国立癌症协会的博士,亦即这项研究的领导者克里斯蒂娜佩尔森说道,通过改进治疗方法可以延长艾滋病的患者的寿命。但是同时,他们罹患各种癌症的风险也增加了。食管癌及胃癌发生的危险性增加以前就已经有观察过,但我们也许可以着重研究患这些恶性肿瘤亚

  根据最近发表在Gastroenterology杂志(即美国胃肠病协会的官方杂志)的一项研究结果指出,艾滋病患者患食管癌、胃癌及非霍奇金淋巴瘤的危险性增加。

  国立癌症协会的博士,亦即这项研究的领导者克里斯蒂娜佩尔森说道,通过改进治疗方法可以延长艾滋病的患者的寿命。但是同时,他们罹患各种癌症的风险也增加了。食管癌及胃癌发生的危险性增加以前就已经有观察过,但我们也许可以着重研究患这些恶性肿瘤亚型的风险。

  在这项研究中,研究人员分析了HIV感染者及艾滋病患者匹配研究的数据,这些数据与收集自1980年至2007年间美国16个州的HIV感染者和艾滋病患者、癌症登记者进行比较。他们比较了596,955名艾滋病患者与普通人群患胃癌和食管癌的危险性的差别。

  艾滋病患者患食管癌、胃癌的风险分别增加69%、44%。食管及胃发生霍奇金淋巴瘤(即免疫细胞相关性肿瘤)的风险也大大提高。此外,研究人员的分析结果表明,艾滋病患者患低位胃癌的危险性增加53%。由于幽门螺杆菌成为这类型胃癌的诱因之一,因此另一个解释是,幽门螺杆菌感染率的增加可能使得艾滋病患者的癌症患病率的增加。

  关于癌症患病风险增加的另一个解释是,可能是由于在艾滋病患者中烟草及酒精摄入的增加。通过鼓励这些病人戒烟及限酒也许可以降低食管癌及胃癌的发生率。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=13934, encodeId=328713934ea, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/27/fbd784adc68b967ee1f6d8d7192692c0.jpg, createdBy=771884322, createdName=zczcz6655, createdTime=Sat Jan 10 21:24:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710613, encodeId=29fc1e10613a0, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Jul 06 20:58:00 CST 2013, time=2013-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071460, encodeId=a33720e146039, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Apr 01 01:58:00 CST 2013, time=2013-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063820, encodeId=6cb8206382065, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Nov 04 06:58:00 CST 2012, time=2012-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504142, encodeId=b1b01504142a2, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Oct 12 06:58:00 CST 2012, time=2012-10-12, status=1, ipAttribution=)]
    2015-01-10 zczcz6655

    很不错的文章

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=13934, encodeId=328713934ea, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/27/fbd784adc68b967ee1f6d8d7192692c0.jpg, createdBy=771884322, createdName=zczcz6655, createdTime=Sat Jan 10 21:24:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710613, encodeId=29fc1e10613a0, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Jul 06 20:58:00 CST 2013, time=2013-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071460, encodeId=a33720e146039, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Apr 01 01:58:00 CST 2013, time=2013-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063820, encodeId=6cb8206382065, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Nov 04 06:58:00 CST 2012, time=2012-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504142, encodeId=b1b01504142a2, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Oct 12 06:58:00 CST 2012, time=2012-10-12, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=13934, encodeId=328713934ea, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/27/fbd784adc68b967ee1f6d8d7192692c0.jpg, createdBy=771884322, createdName=zczcz6655, createdTime=Sat Jan 10 21:24:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710613, encodeId=29fc1e10613a0, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Jul 06 20:58:00 CST 2013, time=2013-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071460, encodeId=a33720e146039, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Apr 01 01:58:00 CST 2013, time=2013-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063820, encodeId=6cb8206382065, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Nov 04 06:58:00 CST 2012, time=2012-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504142, encodeId=b1b01504142a2, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Oct 12 06:58:00 CST 2012, time=2012-10-12, status=1, ipAttribution=)]
    2013-04-01 许安
  4. [GetPortalCommentsPageByObjectIdResponse(id=13934, encodeId=328713934ea, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/27/fbd784adc68b967ee1f6d8d7192692c0.jpg, createdBy=771884322, createdName=zczcz6655, createdTime=Sat Jan 10 21:24:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710613, encodeId=29fc1e10613a0, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Jul 06 20:58:00 CST 2013, time=2013-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071460, encodeId=a33720e146039, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Apr 01 01:58:00 CST 2013, time=2013-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063820, encodeId=6cb8206382065, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Nov 04 06:58:00 CST 2012, time=2012-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504142, encodeId=b1b01504142a2, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Oct 12 06:58:00 CST 2012, time=2012-10-12, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=13934, encodeId=328713934ea, content=很不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/27/fbd784adc68b967ee1f6d8d7192692c0.jpg, createdBy=771884322, createdName=zczcz6655, createdTime=Sat Jan 10 21:24:00 CST 2015, time=2015-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710613, encodeId=29fc1e10613a0, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sat Jul 06 20:58:00 CST 2013, time=2013-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071460, encodeId=a33720e146039, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Apr 01 01:58:00 CST 2013, time=2013-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063820, encodeId=6cb8206382065, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Sun Nov 04 06:58:00 CST 2012, time=2012-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504142, encodeId=b1b01504142a2, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Oct 12 06:58:00 CST 2012, time=2012-10-12, status=1, ipAttribution=)]

相关资讯

NEJM:抗干扰素-γ自身中和抗体与艾滋病样免疫缺陷症相关

干扰素-γ自身抗体与严重弥散性机会性感染相关,但其对于感染流行率的重要性尚需进一步研究。日前,来自于美国马里兰州临床感染病研究所的Sarah K. Browne博士等人发现,抗干扰素-γ自身中和抗体与亚洲艾滋病样免疫缺陷症有关,他们的论文发表于国际权威杂志NEJM 2012年8月23日在线版上。 研究人员共纳入了203例来自台湾和泰国的受试者,并将其分为5组:1组,弥散性,快速或慢性发展的非结核

AIDS and Behavior :HIV家用检测试纸可预防艾滋传播

30年来对HIV流行病学的监控表明,许多HIV感染高风险者不能或不愿采取安全性行为,比如禁欲和使用安全套。这些情况表明在这些(高风险)个体中采取替代方法降低HIV暴露率或传播率有市场空间。纽约艾滋病临床与行为研究中心 Alex Carballo-Dieguez与其同事最近的一个研究项目结果----- HIV家用检测试纸(HT)就是这样的方法之一。 Springer旗下的《AIDS and

Sci Transl Med:研究者发现潜在的艾滋病治疗新靶点

近日,美国加州大学旧金山分校(UCSF)的研究者通过研究发现,在实验室感染猿猴免疫缺陷病毒(SIV)的猕猴,因其机体肠道内有某种特定类型的免疫细胞,相比其它猴类血液中的病毒量水平较低,而且感染6个月后,猕猴可以自如地控制SIV。SIV是一种可以感染灵长类动物的反转录病毒,人类感染SIV后可以慢慢发展为HIV感染。在猕猴中SIV可以促使猴艾滋病,因此在动物中研究SIV可以为理解HIV如何在人体内发挥

我国艾滋疫苗进入Ⅱ期临床试验

  8月14日,由国家科技重大专项支持、我国拥有自主知识产权的艾滋病疫苗正式进入Ⅱ期临床试验,首批15名志愿者在北京佑安医院接受了疫苗接种。领衔该重大专项研究的中国疾病预防控制中心邵一鸣研究员称,此次临床试验主要目标是进一步评价该疫苗的安全性和免疫原性,并确定其免疫程序,从而为开展大规模检验疫苗有效性的临床试验作准备。据悉,这是世界上使用复制型活病毒载体研制的艾滋病疫苗首次进入Ⅱ期临床试验。  

联合国发布全球艾滋病新数据

(记者赵路)联合国艾滋病规划署(UNAIDS)最新出版的一份传染病更新数据显示,截至2011年年末,全世界共有3420万名艾滋病病毒(HIV)感染者,比一年前的3350万HIV感染者略有增长。从某种意义上说,这一增长是一个好消息,因为它反映了这样一个事实,即有更多的被感染者正在接受抗逆转录病毒(ARV)药物的治疗,从而减少了因艾滋病(AIDS)死亡的人数。   这份长达135页的报告

PLoS ONE:大麻样化合物抑制HIV

据期刊PLoS ONE上发表的文章报道,纽约西奈山医学院研究人员发现大麻样化合物可触发人免疫细胞受体,能直接抑制艾滋病(AIDS)晚期阶段的人免疫缺陷病毒(HIV)。 医用大麻常用来止痛、缓解消瘦和厌食及晚期艾滋病的副反应。本研究首次揭示免疫细胞的大麻受体(即大麻素受体CB1和CB2)能影响病毒传播。了解该受体对病毒的作用有助于开发减缓AIDS进程的新药物。 HIV常感染携带病毒受体CD4