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内源性代谢调节剂AXA1125作为非酒精性脂肪肝候选药，临床数据证实调节肝脏代谢、炎症和纤维化

2019-01-25 MedSci MedSci原创

非酒精性脂肪肝肝纤维化内源性代谢调节
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从体内外结果和IRB批准的临床研究表明AXA1125：降低人肝细胞中的甘油三酯； 抑制有氧糖酵解，同时保留人巨噬细胞中的总ATP水平； 减少ProC3和其他关键纤维化标志物，包括减少人类星状细胞的活化和增殖。

Axcella Health是一家致力于解决代谢失调和健康的生物技术公司，它在NASH和NAFLD Keystone Symposium综合疾病研讨会上提供了有关该公司AXA1125计划的新数据。新数据由Axcella发现高级主管Svetlana Marukian博士的口头报告介绍。

Axcella Health公司的新药AXA1125是一种新型内源性代谢调节物，旨在解决肝脏健康相关的代谢、炎症和纤维化现象。

从体内外结果和IRB批准的临床研究表明AXA1125：降低人肝细胞中的甘油三酯； 抑制有氧糖酵解，同时保留人巨噬细胞中的总ATP水平； 减少ProC3和其他关键纤维化标志物，包括减少人类星状细胞的活化和增殖。

Axcella临床开发高级副总裁兼首席医疗官Manu Chakravarthy说："这些数据证明了内源性代谢调节物代表了一种新型的、可以解决复杂疾病疗法。"

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    2019-02-11 diushouji

    #内源性#

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    2019-11-28 yangshch

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    2019-05-03 chenlianhui

    #临床数据#

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非酒精性脂肪肝在世界范围内的流行性在逐渐增高，与此相同的是糖尿病和代谢综合征也在世界范围内流行起来。非酒精性脂肪肝疾病，是从非酒精性脂肪肝到非酒精性脂肪肝炎的连续肝脏异常，这个变化的过程还会导致肝硬化和肝癌的发生。非酒精性脂肪肝炎的诊断通常考虑到转氨酶的升高或对腹部成像偶然发现肝脏脂肪。而对于非酒精性脂肪肝，其诊断依据比较的不常见，通常当代谢并发症出现时患者可能就怀疑患有此病。肝脂肪变性可以通过影