Chest:一种用于周围型肺癌可以同时成像和光疗的新型激光纤维镜

2019-04-28 xiangting MedSci原创

这种新型激光装置可以实现周围型肺癌的超微创、经支气管治疗。

对于无法手术切除的局部非小细胞肺癌患者,光疗是一种替代疗法。然而,光疗目前仅限于治疗中心部位的肺癌,而更大比例的外周病变仍无法到达。由于在治疗期间需要转换可视化和辐射纤维,这阻止了操作者确认辐射纤维的最终位置,所以还存在靶向激光治疗准确性的担忧。

该研究在临床肺癌模型中评估了一种新开发的平行型超小复合光学纤维内窥镜(Laser-eYe超薄纤维内窥镜;LYU),它能同时实现白光成像和光疗。使用了3种模型:小鼠中的人肺癌异种移植物(A549)、兔中的原位VX2肺肿瘤和移植了A549肿瘤组织的离体猪肺。使用多功能卟啉-磷脂纳米粒子(卟啉体)作为光敏剂以评价荧光引导的光热疗法。

LYU的0.97mm直径和亲水涂层可以轻松通过所有类型支气管镜的工作通道,并可以在任何所需方向上控制LYU尖端的引导。LYU可以观察到外周支气管和负荷卟啉的外周肿瘤。LYU还可以同时进行成像和光热疗法。

LYU可以同步实现成像和光疗,使得周围型肺癌得到准确辐射。这种新型激光装置可以实现周围型肺癌的超微创、经支气管治疗。

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    2019-07-08 Smile2680
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    2019-10-31 俅侠
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    2019-04-30 oliver169

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