Eur Heart J：近红外光谱导出的LCBI可预测冠心病患者长期随访时不良心血管结局

2017-05-27 MedSci MedSci原创

近红外光谱（Near-infrared spectroscopy，NIRS）能量化冠状动脉内的胆固醇的脂质核心负荷指数（LCBI）。研究人员研究了在冠状动脉疾病（CAD）患者中长期随访心脏不良结局时，由近红外光谱导出的LCBI的预后情况。研究共纳入了2009-2013年间，在275例经冠状动脉造影确诊的急性冠脉综合征（ACS）和稳定型心绞痛患者的非梗死动脉的近红外光谱数据。通过独立的corelab

近红外光谱（Near-infrared spectroscopy，NIRS）能量化冠状动脉内的胆固醇的脂质核心负荷指数（LCBI）。研究人员研究了在冠状动脉疾病（CAD）患者中长期随访心脏不良结局时，由近红外光谱导出的LCBI的预后情况。

研究共纳入了2009-2013年间，在275例经冠状动脉造影确诊的急性冠脉综合征（ACS）和稳定型心绞痛患者的非梗死动脉的近红外光谱数据。通过独立的corelab对感兴趣区域(LCBIROI)和4mm或10mm的最大LCBI(MaxLCBI4mm and MaxLCBI10mm)的分析来量化LCBI。主要终点是主要的心脏不良事件（MACE），被定义为全因死亡、非致死性ACS或临时血运重建的复合发生。调整年龄、性别、临床危险因素和血管内超声确定的段斑块负荷后得出危险因素（HR）。

研究人员对患者中位随访4.1 年期间，79例患者（28.7%）出现了主要的心脏不良事件。较高的MaxLCBI4mm值与MACE高风险之间的联系具有统计学意义且独立连续。MaxLCBI4mm每100单位的增加都与MACE风险增加19%相关（HR 1.19，95%CI：1.07-1.32，P = 0.001）。排除目标损伤相关事件后，连续MaxLCBI4mm与MACE依然独立相关（HR 1.21，95% CI：1.08-1.35），同样在排除近红外光谱成像的冠状动脉段相关的不良事件后（HR 1.19，95% CI：1.06-1.34）。MaxLCBI10mm的结果与MaxLCBI4mm相似。

研究人员认为NIRS导出的LCBI与冠心病患者长期随访时的心脏不良预后相关，且独立于临床风险因素和斑块负荷。

原始出处：

Schuurman AS, Vroegindewey M,et al.Near-infrared spectroscopy-derived lipid core burden index predicts adverse cardiovascular outcome in patients with coronary artery disease during long-term follow-up.Eur Heart J. 2017 May 20. doi: 10.1093/eurheartj/ehx247. [Epub ahead of print]

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2018-04-15 crystal0562

#长期随访#

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2017-11-29 gaoxiaoe

#近红外#

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2018-01-19 lixiao3326

#红外光谱#

46 0
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2017-05-31 为你把脉

v哈哈很过分反反复复

66 0
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2017-05-29 为你把脉

vghhhhgggh

71 0
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2017-05-29 gous

#心血管结局#

29 0
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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat May 27 17:13:13 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
2017-05-29 zhaojie88

#ART#

22 0
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createdName=gaoxiaoe, createdTime=Wed Nov 29 21:05:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804430, encodeId=cf00180443005, content=<a href='/topic/show?id=4047e71155a' target=_blank style='color:#2F92EE;'>#红外光谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77115, encryptionId=4047e71155a, topicName=红外光谱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Fri Jan 19 04:05:00 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204684, encodeId=10ab2046845e, content=v哈哈很过分反反复复, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Wed May 31 07:11:16 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204064, encodeId=b55a2040644c, content=vghhhhgggh, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Mon May 29 17:19:44 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269310, encodeId=b60d1269310d2, content=<a href='/topic/show?id=49d1518915a' target=_blank style='color:#2F92EE;'>#心血管结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51891, encryptionId=49d1518915a, topicName=心血管结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9987, createdName=gous, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356287, encodeId=488d135628ecd, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447695, encodeId=0619144e6950b, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99445365987, createdName=liubm557, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562538, encodeId=cad41562538c7, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203265, encodeId=276520326523, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat May 27 17:13:13 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
2017-05-29 liubm557

#冠心病患者#

30 0
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createdName=gaoxiaoe, createdTime=Wed Nov 29 21:05:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804430, encodeId=cf00180443005, content=<a href='/topic/show?id=4047e71155a' target=_blank style='color:#2F92EE;'>#红外光谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77115, encryptionId=4047e71155a, topicName=红外光谱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Fri Jan 19 04:05:00 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204684, encodeId=10ab2046845e, content=v哈哈很过分反反复复, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Wed May 31 07:11:16 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204064, encodeId=b55a2040644c, content=vghhhhgggh, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Mon May 29 17:19:44 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269310, encodeId=b60d1269310d2, content=<a href='/topic/show?id=49d1518915a' target=_blank style='color:#2F92EE;'>#心血管结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51891, encryptionId=49d1518915a, topicName=心血管结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9987, createdName=gous, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356287, encodeId=488d135628ecd, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447695, encodeId=0619144e6950b, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99445365987, createdName=liubm557, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562538, encodeId=cad41562538c7, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203265, encodeId=276520326523, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat May 27 17:13:13 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
2017-05-29 slcumt

#HEART#

28 0
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createdName=gaoxiaoe, createdTime=Wed Nov 29 21:05:00 CST 2017, time=2017-11-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1804430, encodeId=cf00180443005, content=<a href='/topic/show?id=4047e71155a' target=_blank style='color:#2F92EE;'>#红外光谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77115, encryptionId=4047e71155a, topicName=红外光谱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Fri Jan 19 04:05:00 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204684, encodeId=10ab2046845e, content=v哈哈很过分反反复复, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Wed May 31 07:11:16 CST 2017, time=2017-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=204064, encodeId=b55a2040644c, content=vghhhhgggh, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b0171930782, createdName=为你把脉, createdTime=Mon May 29 17:19:44 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269310, encodeId=b60d1269310d2, content=<a href='/topic/show?id=49d1518915a' target=_blank style='color:#2F92EE;'>#心血管结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51891, encryptionId=49d1518915a, topicName=心血管结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9987, createdName=gous, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356287, encodeId=488d135628ecd, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447695, encodeId=0619144e6950b, content=<a href='/topic/show?id=523a3082670' target=_blank style='color:#2F92EE;'>#冠心病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30826, encryptionId=523a3082670, topicName=冠心病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99445365987, createdName=liubm557, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562538, encodeId=cad41562538c7, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon May 29 07:05:00 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203265, encodeId=276520326523, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat May 27 17:13:13 CST 2017, time=2017-05-27, status=1, ipAttribution=)]
2017-05-27 wxl882001

学习一下

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心血管

Eur Heart J：近红外光谱导出的LCBI可预测冠心病患者长期随访时不良心血管结局

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