J Periodontol:Histatin-1抵消内皮和成骨细胞样细胞内唑来膦酸的毒性及抗迁移作用

2019-01-30 lishiting MedSci原创

唑来膦酸是导致双膦酸盐相关颌骨坏死(BRONJ)最常见的物质,对骨和血管细胞具有毒性作用。因此,研发一种可以中和其毒性作用的全新方法对于探索BRONJ的预防疗法具有十分重要的意义。近来研究发现,唾液肽Histatin-1可以通过作用于上皮及内皮细胞促进口腔伤口的愈合;然而,它对暴露于唑来膦酸的细胞的作用还未可知。这篇研究的目的是为了评估Histatin-1对施加了唑来膦酸刺激的成骨和血管细胞系的作

唑来膦酸是导致双膦酸盐相关颌骨坏死(BRONJ)最常见的物质,对骨和血管细胞具有毒性作用。因此,研发一种可以中和其毒性作用的全新方法对于探索BRONJ的预防疗法具有十分重要的意义。近来研究发现,唾液肽Histatin-1可以通过作用于上皮及内皮细胞促进口腔伤口的愈合;然而,它对暴露于唑来膦酸的细胞的作用还未可知。这篇研究的目的是为了评估Histatin-1对施加了唑来膦酸刺激的成骨和血管细胞系的作用。研究通过细胞毒性(Trypan Blue exclusion)和细胞迁移(Boyden Chamber)试验评估唑来膦酸(1-100μM), Histatin-1 (10μM)或2者联合应用的效果。通过WB检测Caspase-3的表达。通过体外小管形成试验检测内皮细胞的血管生成能力。结果显示,唑来膦酸以剂量依赖的模式减弱骨肉瘤细胞(SAOS-2)和成骨前体细胞(MC3T3-E1)的细胞活力及迁移能力。而Histatin-1可以抵消唑来膦酸作用,恢复2种细胞系的细胞活力和迁移能力。这些作用在内皮细胞(EA.hy926)中也同样存在,Histatin-1可以中和唑来膦酸的毒性和抗迁移作用,体外

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    2019-10-22 yuanming17
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    2019-06-26 feather89
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    2019-12-31 DEXTER3139
  4. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359656, encodeId=752c3596566c, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Jan 31 10:34:27 CST 2019, time=2019-01-31, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1703642, encodeId=e7a11e03642c6, content=<a href='/topic/show?id=9b00886536' target=_blank style='color:#2F92EE;'>#HIS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8865, encryptionId=9b00886536, topicName=HIS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133330532258, createdName=yuanming17, createdTime=Tue Oct 22 05:47:00 CST 2019, time=2019-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727871, encodeId=77f91e278718f, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359656, encodeId=752c3596566c, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Jan 31 10:34:27 CST 2019, time=2019-01-31, status=1, ipAttribution=)]
    2019-03-31 snowpeakxu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1703642, encodeId=e7a11e03642c6, content=<a href='/topic/show?id=9b00886536' target=_blank style='color:#2F92EE;'>#HIS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8865, encryptionId=9b00886536, topicName=HIS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133330532258, createdName=yuanming17, createdTime=Tue Oct 22 05:47:00 CST 2019, time=2019-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727871, encodeId=77f91e278718f, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359656, encodeId=752c3596566c, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Jan 31 10:34:27 CST 2019, time=2019-01-31, status=1, ipAttribution=)]
    2019-02-01 zhaojie88
  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359656, encodeId=752c3596566c, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Jan 31 10:34:27 CST 2019, time=2019-01-31, status=1, ipAttribution=)]
  8. 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  9. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359656, encodeId=752c3596566c, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Jan 31 10:34:27 CST 2019, time=2019-01-31, status=1, ipAttribution=)]
    2019-02-01 yjs木玉

    好好好好好好

    0

  10. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359656, encodeId=752c3596566c, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Jan 31 10:34:27 CST 2019, time=2019-01-31, status=1, ipAttribution=)]
    2019-01-31 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0