Circulation:心血管病风险预测中国模型

2016-10-12 MedSci MedSci原创

如果能够知道10年后,每个人罹患急性心肌梗死、脑卒中等动脉粥样硬化性心血管疾病(ASCVD)的风险,就可以提前预警。日前,由中国医学科学院阜外医院副院长顾东风教授领衔的团队,顺利完成了中国ASCVD风险预测研究(简称China-PAR)。通过输入年龄、总胆固醇、高密度脂蛋白胆固醇、糖尿病等综合指标数据,便能够借助数学模型,计算出10年后个人ASCVD的发病风险。近日,这一研究成果论文在著名国际医学

如果能够知道10年后,每个人罹患急性心肌梗死、脑卒中等动脉粥样硬化性心血管疾病(ASCVD)的风险,就可以提前预警。日前,由中国医学科学院阜外医院副院长顾东风教授领衔的团队,顺利完成了中国ASCVD风险预测研究(简称China-PAR)。通过输入年龄、总胆固醇、高密度脂蛋白胆固醇糖尿病等综合指标数据,便能够借助数学模型,计算出10年后个人ASCVD的发病风险。近日,这一研究成果论文在著名国际医学期刊《循环》杂志在线发表。

冠状动脉粥样硬化性心脏病和脑卒中,是我国居民健康的首要威胁。然而,目前关于ASCVD发病风险的预测模型多来自欧美人群,并不一定适用于我国人群。China-PAR研究是利用中国人群最新的“中国心血管健康多中心合作研究”(InterASIA)、“中国心血管病流行病学多中心协作研究”(ChinaMUCA)等4项前瞻性队列随访数据(共计10.6万人),开发和验证的首个ASCVD发病风险预测“中国模型”。模型构建过程中,不仅综合考虑了既往欧美国家风险预测模型中涉及的年龄、收缩压、总胆固醇等危险因素,还根据中国实际情况和疾病谱特点,考虑了南北方居住地区和城乡差别,并纳入腰围、ASCVD家族史,以及年龄与各危险因素的交互作用等综合因素。

模型建立后,经过China-PAR模型的内部验证,以及在1.4万人和7.1万人两个随访人群中的外部验证,证实China-PAR模型具有良好的预测能力。研究也证实,与美国相关模型相比,China-PAR模型对中国人群10年ASCVD发病风险的预测更加准确。

顾东风表示,China-PAR模型为我国心血管疾病的一级预防提供了实用性评估工具。研究者建议,根据既往心血管病防治指南及本项目的队列分析,如果10年ASCVD发病风险超过10%,可视为心血管病高危人群;而发病风险在5%~10%,可视为中危人群;小于5%为低危人群。对于低危人群,应该加强自我监测以及ASCVD终身风险评估;对于中危人群,应积极改变不良生活方式,如戒烟、控制体重等;对于高危人群,除上述生活方式改变之外,应该针对自身的危险因素,在医生指导下进行降压、调脂、降糖等药物治疗,并在采取相关干预措施一段时间后,评估自身ASCVD发病风险的变化

10年内发生动脉粥样硬化性心血管病(ASCVD)危险度评估(China-PAR)

原始出处:

Yang X, Li J, Hu D, Chen J, Li Y, Huang J, Liu X, Liu F, Cao J, Shen C, Yu L, Lu F, Wu X, Zhao L, Wu X, Gu D. Predicting the Ten-Year Risks of Atherosclerotic Cardiovascular Disease in Chinese Population: The China-PAR Project. Circulation. 2016 Sep 28. pii: CIRCULATIONAHA.116.022367


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    2016-10-14 1de48adem68(暂无匿称)

    可以拿来试试看

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    2016-10-12 doctorJiangchao

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    2016-10-12 doctorJiangchao

    继续学习

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