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Dent Mater J：牙科复合树脂单体对牙髓细胞的影响

2019-06-18 lishiting MedSci原创

树脂单体毒性
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牙科用多种材料均含有甲基丙烯酸酯单体，它会导致牙髓细胞毒性但其毒性机制却不清楚。这篇研究的目的是通过培养的人牙髓细胞评估3种常用单体bisphenol-A-glycidyl methacrylate (Bis-GMA), urethane dimethacrylate (UDMA)和triethyleneglycol dimethacrylate (TEGDMA)的影响。

牙科用多种材料均含有甲基丙烯酸酯单体，它会导致牙髓细胞毒性但其毒性机制却不清楚。这篇研究的目的是通过培养的人牙髓细胞评估3种常用单体bisphenol-A-glycidyl methacrylate (Bis-GMA)， urethane dimethacrylate (UDMA)和triethyleneglycol dimethacrylate (TEGDMA)的影响。

结果显示，三种单体毒性的顺序为Bis-GMA>UDMA>TEGDMA。细胞毒性与胱氨酸摄入程度相反。Bis-GMA和UDMA诱导氧化应激反应，而不是TEGDMA。毒性与谷胱甘肽水平关联不大，因为所有化合物都降低了细胞内的谷胱甘肽。TEGDMA的毒性低于Bis-GMA和UDMA，这可能是因为它刺激了胱氨酸摄入以及并未诱导氧化应激反应，而增强的胱氨酸摄入能够补偿TEGDMA's与谷胱甘肽的直接作用。Bis-GMA和UDMA均消耗谷胱甘肽并抑制胱氨酸摄入，进而导致氧化应激反应和细胞死亡。

原始出处：

Schneider TR， Hakami-Tafreshi R， et al. Effects of dental composite resin monomers on dental pulp cells. Dent Mater J. 2019 May 17. doi： 10.4012/dmj.2018-163.

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    2020-04-27 mnda

    #牙髓细胞#

    0

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    2019-09-13 jxrzshh

    #牙髓#

    0

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    2019-06-20 zhaojie88

    #牙科#

    0

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    2019-06-20 chengjn

    #髓细胞#

    0

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    2019-06-20 guozhenyu

    #复合树脂#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1724359, encodeId=f0461e2435904, content=<a href='/topic/show?id=e1f56e68935' target=_blank style='color:#2F92EE;'>#牙髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67689, encryptionId=e1f56e68935, topicName=牙髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7f2d33606535, createdName=mnda, createdTime=Mon Apr 27 17:21:00 CST 2020, time=2020-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669785, encodeId=2e3e1669e850f, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Fri Sep 13 00:21:00 CST 2019, time=2019-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461357, encodeId=9fec146135e98, content=<a href='/topic/show?id=67356e62003' target=_blank style='color:#2F92EE;'>#牙科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67620, encryptionId=67356e62003, topicName=牙科)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jun 20 01:21:00 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468202, encodeId=11731468202ba, content=<a href='/topic/show?id=71c810212946' target=_blank style='color:#2F92EE;'>#髓细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102129, encryptionId=71c810212946, topicName=髓细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=69e46898758, createdName=chengjn, createdTime=Thu Jun 20 01:21:00 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1476664, encodeId=e3b614e6664f2, content=<a href='/topic/show?id=d6b9426165e' target=_blank style='color:#2F92EE;'>#复合树脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42616, encryptionId=d6b9426165e, topicName=复合树脂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c8a7309244, createdName=guozhenyu, createdTime=Thu Jun 20 01:21:00 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627587, encodeId=b439162e5874f, content=<a href='/topic/show?id=cea46199eba' target=_blank style='color:#2F92EE;'>#树脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61997, encryptionId=cea46199eba, topicName=树脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=378b21121654, createdName=chenshujs, createdTime=Thu Jun 20 01:21:00 CST 2019, time=2019-06-20, status=1, ipAttribution=)]
    2019-06-20 chenshujs

    #树脂#

    0