五类患者禁用硝酸甘油

2018-01-21 河南大学第一附属医院临床药学室主管药师 寇 威 人民网-生命时报

以硝酸甘油为代表的硝酸酯类药物是治疗心绞痛最古老、最常用的特效药,临床上已应用近140年。因其治疗冠心病、心绞痛疗效可靠,在新药不断涌现的今天,仍是心血管病治疗中使用最为广泛的药物之一。

以硝酸甘油为代表的硝酸酯类药物是治疗心绞痛最古老、最常用的特效药,临床上已应用近140年。因其治疗冠心病、心绞痛疗效可靠,在新药不断涌现的今天,仍是心血管病治疗中使用最为广泛的药物之一。

硝酸甘油通过扩张冠状动脉、外周静脉和动脉,增加冠状动脉血液和氧的供应,降低心肌耗氧量,改善心肌缺血和缺氧状态,缓解心绞痛症状。然而,并非所有的心绞痛都能够使用硝酸甘油。以下这5类患者,要尤其注意。

1.青光眼患者,尤其是原发性闭角型青光眼,且未经手术治疗者,应用硝酸甘油后会使眼压进一步升高,加剧眼痛,甚至出现更严重的反应。如非用不可,则需密切监测眼压及症状。已经手术治疗的闭角型青光眼或药物控制良好的开角型青光眼患者,可以使用,但需定期监测眼压。如用药后发生了视物模糊、鼻根部酸胀、眼部胀痛、头痛、恶心、眼红、怕光、流泪等不适症状,应立即到眼科就诊。

2.低血压患者。低血压患者或平常血压偏低的患者应谨慎使用硝酸甘油,因为硝酸甘油在扩张冠状动脉血管的同时,也会扩张其他血管,使血压降得更低,尤其在体位突然变动时更易发生。

3.脑出血、颅内压增高患者。硝酸甘油会扩张脑血管,使原有病情加重,因此脑出血、颅内压增高患者应慎用硝酸甘油。

4.肥厚型梗阻性心肌病患者。硝酸甘油会使该病患者左心室流出道梗阻进一步加重,甚至引起晕厥、猝死,应尽量避免应用。

5.正在应用西地那非的患者。西地那非即人们常说的“伟哥”,商品名叫“万艾可”。西地那非会增强硝酸甘油的降压作用,因此两种药物不能一起服用,以免引起严重低血压甚至猝死。

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=281369, encodeId=34eb2813693f, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Jan 23 22:32:32 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309331, encodeId=cb471309331f9, content=<a href='/topic/show?id=9faae35400d' target=_blank style='color:#2F92EE;'>#硝酸甘油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73540, encryptionId=9faae35400d, topicName=硝酸甘油)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Jan 23 10:04:00 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280905, encodeId=4b91280905d3, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Mon Jan 22 09:07:56 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280775, encodeId=4b54280e751a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/22/005b55a98a8b2e8ec8bd5577813de704.jpg, createdBy=29fc2176768, createdName=祝您健康, createdTime=Sun Jan 21 22:28:03 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280760, encodeId=2017280e60a4, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Jan 21 20:14:38 CST 2018, time=2018-01-21, status=1, ipAttribution=)]
    2018-01-23 1e1b8538m79(暂无匿称)

    不错的文章.值得拥有

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=281369, encodeId=34eb2813693f, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Jan 23 22:32:32 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309331, encodeId=cb471309331f9, content=<a href='/topic/show?id=9faae35400d' target=_blank style='color:#2F92EE;'>#硝酸甘油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73540, encryptionId=9faae35400d, topicName=硝酸甘油)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Jan 23 10:04:00 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280905, encodeId=4b91280905d3, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Mon Jan 22 09:07:56 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280775, encodeId=4b54280e751a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/22/005b55a98a8b2e8ec8bd5577813de704.jpg, createdBy=29fc2176768, createdName=祝您健康, createdTime=Sun Jan 21 22:28:03 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280760, encodeId=2017280e60a4, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Jan 21 20:14:38 CST 2018, time=2018-01-21, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=281369, encodeId=34eb2813693f, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Jan 23 22:32:32 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309331, encodeId=cb471309331f9, content=<a href='/topic/show?id=9faae35400d' target=_blank style='color:#2F92EE;'>#硝酸甘油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73540, encryptionId=9faae35400d, topicName=硝酸甘油)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Jan 23 10:04:00 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280905, encodeId=4b91280905d3, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Mon Jan 22 09:07:56 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280775, encodeId=4b54280e751a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/22/005b55a98a8b2e8ec8bd5577813de704.jpg, createdBy=29fc2176768, createdName=祝您健康, createdTime=Sun Jan 21 22:28:03 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280760, encodeId=2017280e60a4, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Jan 21 20:14:38 CST 2018, time=2018-01-21, status=1, ipAttribution=)]
    2018-01-22 半夏微凉

    学习了谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=281369, encodeId=34eb2813693f, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Jan 23 22:32:32 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309331, encodeId=cb471309331f9, content=<a href='/topic/show?id=9faae35400d' target=_blank style='color:#2F92EE;'>#硝酸甘油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73540, encryptionId=9faae35400d, topicName=硝酸甘油)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Jan 23 10:04:00 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280905, encodeId=4b91280905d3, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Mon Jan 22 09:07:56 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280775, encodeId=4b54280e751a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/22/005b55a98a8b2e8ec8bd5577813de704.jpg, createdBy=29fc2176768, createdName=祝您健康, createdTime=Sun Jan 21 22:28:03 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280760, encodeId=2017280e60a4, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Jan 21 20:14:38 CST 2018, time=2018-01-21, status=1, ipAttribution=)]
    2018-01-21 祝您健康

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=281369, encodeId=34eb2813693f, content=不错的文章.值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Tue Jan 23 22:32:32 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309331, encodeId=cb471309331f9, content=<a href='/topic/show?id=9faae35400d' target=_blank style='color:#2F92EE;'>#硝酸甘油#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73540, encryptionId=9faae35400d, topicName=硝酸甘油)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Tue Jan 23 10:04:00 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280905, encodeId=4b91280905d3, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Mon Jan 22 09:07:56 CST 2018, time=2018-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280775, encodeId=4b54280e751a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/22/005b55a98a8b2e8ec8bd5577813de704.jpg, createdBy=29fc2176768, createdName=祝您健康, createdTime=Sun Jan 21 22:28:03 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280760, encodeId=2017280e60a4, content=学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sun Jan 21 20:14:38 CST 2018, time=2018-01-21, status=1, ipAttribution=)]
    2018-01-21 天地飞扬

    学习了.谢谢分享!

    0

相关资讯

血管扩张药物之三大“硝”雄,有铠甲,也有软肋......

血管扩张药物之三大“硝”雄——硝酸甘油、硝酸异山梨酯、单硝酸异山梨酯,是大家熟知的血管平滑肌扩张药。但三者各有“铠甲”也有“软肋”,其差异之处鲜为人知。那么,接下来,大家跟随笔者一起揭秘“硝”氏三雄的真面目,知己知彼,方可运筹帷幄。

喝酒脸红的人,需要慎用3类药 !

喝酒脸红的罪魁祸首,不是乙醇,而是乙醛。在体内,酒精首先经催化变成乙醛,然后在乙醛脱氢酶2的作用下进一步分解。如果这种酶的活性出了问题,乙醛无法被及时代谢,大量滞留在体内,可能舒张面部血管,引起脸红,严重时可能对心、脑、肝、肾等器官造成伤害。喝酒容易脸红的人在服药时应谨慎,尤其要慎用以下三类药: 1、硝酸甘油:紧急用药,可能无效众所周知,心绞痛发作如不及时治疗,可能引起急性心肌梗死,甚至因严重心律

J Am Coll Cardiol:看看硝酸甘油和其他氮氧化物在心血管治疗中都有哪些作用

2017年美国科学家在《J Am Coll Cardiol》发文,介绍了硝酸甘油和其他氮氧化物在心血管治疗中的作用。

选速效救心丸,还是硝酸甘油?(修订)

硝酸甘油和速效救心丸,都称得上是心绞痛患者的“救命药”。那么,在心绞痛急性发作时,到底是应该选用硝酸甘油还是速效救心丸?这两种药之间究竟怎样区别呢?一、两种药均可用于心绞痛急性发作心绞痛为冠状动脉血流量不能满足心脏需要,心肌急剧的、暂时的缺血、缺氧所引起。硝酸甘油片和速效救心丸均可用于冠心病心绞痛的治疗及预防(药品说明书)。硝酸甘油片硝酸甘油是救治心绞痛发作的首选药物。可用于冠心病心绞痛的治疗

Circulation:心绞痛的生理学及硝酸甘油减轻心绞痛的机制

心导管实验室的方案提供了一种研究心肌缺血和已知抗心绞痛药物机制的模型。使用GTN引起全身和冠状动脉循环的变化,既减少心肌需氧量又增加供应,从而减轻运动性缺血。

牢记三点,合理使用硝酸甘油!

硝酸甘油作为硝酸酯类抗心绞痛的代表药之一,尤其是治疗稳定型心绞痛的首选药,可以用于预防疾病发作,控制急性发作,和发作频繁的重症心绞痛患者。其有起效快,毒副作用相对较小、疗效肯定、使用方便实惠等优点,得到了广泛的应用