PNAS:大麻对大脑结构的长期影响

2014-11-11 佚名 神秘的地球

一项研究提出,长期使用大麻对大脑结构的影响可能取决于首次使用的年龄以及使用的时间跨度。Francesca M. Filbey及其同事研究了大脑结构与连通性的改变,考虑到了诸如性别、年龄、民族、首次使用大麻的年龄,以及使用的时间跨度等可能的偏差。这组作者研究了48名成年大麻使用者与62名性别和年龄匹配的非使用者,他们报告了大脑灰质容量和白质连通性方面的几个差异。这些发现提示长期使用大麻可能与灰质容量



一项研究提出,长期使用大麻对大脑结构的影响可能取决于首次使用的年龄以及使用的时间跨度。Francesca M. Filbey及其同事研究了大脑结构与连通性的改变,考虑到了诸如性别、年龄、民族、首次使用大麻的年龄,以及使用的时间跨度等可能的偏差。

这组作者研究了48名成年大麻使用者与62名性别和年龄匹配的非使用者,他们报告了大脑灰质容量和白质连通性方面的几个差异。这些发现提示长期使用大麻可能与灰质容量减少以及眶额叶皮质(OFC)这个结构中的结构与功能性连通性增加有关联。额外的测试揭示出了定期使用大麻出现得早可能与白质的功能连通性增加有关联,而长期使用大麻可能与结构连通性的减少有关联。

这项研究提供了一个初步的迹象,表明就大麻对精神起作用的主要成分δ-9-四氢大麻酚而言,眶额叶皮质(OFC)的灰质可能比白质对其表现得更脆弱。

这组作者说,这项研究提示,长期使用大麻可能调控复杂的神经适应性过程,但是需要进一步的研究从而确定这些变化在结束使用大麻之后是不是可逆的。

原文出处:

Francesca M. Filbey, Sina Aslan, Vince D. Calhoun, Jeffrey S. Spence, Eswar Damaraju,Arvind Caprihan, and Judith Segall. Long-term effects of marijuana use on the brain. PNAS, November 10, 2014; 

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    2015-09-24 drwjr
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    2014-11-13 kcb069
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    2014-11-13 wmr116

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