NEJM:痛风未经治疗后会怎么样?

2022-02-07 Shirley MedSci原创

一则未经降尿酸治疗后,患者关节炎持续恶化的案例。

一名患有痛风和慢性肾病的 65 岁男性因 5 年的手、脚和膝盖关节疼痛和肿胀而到皮肤科就诊。在这 5 年中,他间歇性地接受了痛风药物治疗,并有相关的短暂改善期;然而,他并没有持续接受长期药物治疗,而且他的关节炎不断恶化。

在体格检查中,他的手(图 A)、脚和膝关节有多个痛风石和畸形。他被转诊到风湿病诊所进行进一步评估和治疗。实验室研究显示血清尿酸水平为 9.6 mg/dL(570 μmol/L;参考范围,3.5 至 7.0 mg/dL [210 至 420 μmol/L])和血清肌酐水平为 1.8 mg/dL(160 μmol/L升;参考范围,0.7 至 1.2 mg/dL [60 至 110 μmol/L])。

右脚第一跖趾关节的关节穿刺术产生了粘稠的白色渗出液;在偏光显微镜下可见许多单钠尿酸盐晶体(图 B)。开始降尿酸治疗。随访10个月,患者关节疼痛和肿胀明显减轻。

文章来源:N Engl J Med 2021;385:e97  DOI: 10.1056/NEJMicm2112548

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    2022-03-27 swj851016

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    2022-02-17 huitailang

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    2022-02-13 ms5000000518166734

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    2022-02-10 陈宪

    规范诊疗最重要

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    2022-02-08 查查佳佳

    2022临床大数据分析系列课程报名表

    0

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