机器人科学家"夏娃"，研发药物顶呱呱

2015-02-06 佚名生物谷

  图：机器人科学家 “夏娃” 2015年2月6日讯 /生物谷BIOON/ -- 技术发明永不止步。英国曼彻斯特大学的研究人员最近声称他们研究出了新一代机器人科学家，用于药物研发，降低研发成本。这位科研新星--"夏娃"女士已经成功的发现了一种具有抗肿瘤特性的化合物能同时应用于疟疾的治疗。在科学研究自动化和机械化的趋势下，机器人科学家应运而生。2009年阿伯里斯特威斯和剑桥大学就已

图：机器人科学家 “夏娃”

2015年2月6日讯 /生物谷BIOON/ -- 技术发明永不止步。英国曼彻斯特大学的研究人员最近声称他们研究出了新一代机器人科学家，用于药物研发，降低研发成本。这位科研新星--"夏娃"女士已经成功的发现了一种具有抗肿瘤特性的化合物能同时应用于疟疾的治疗。

在科学研究自动化和机械化的趋势下，机器人科学家应运而生。2009年阿伯里斯特威斯和剑桥大学就已经研发了第一个科学机器人"亚当"。这群新型科学家能自动开发；根据观察测试假说；进行实验；解释结果修正自己的假设；然后重复循环，自动高通量进行假设研究。机器人科学家同样非常适合记录科学知识：由于实验构思和执行皆由计算机自动执行的，所以它可以完全捕捉和数字化记录的科学研究过程的各个方面。"亚当"发明之后，同一科研队伍在曼彻斯特大学又研发出了"夏娃"，应用于药物研发中的早期设计。

首先，"夏娃"机器人能够每天系统地甄别超过1万种化合物。利用其人工智能，根据她的早期的筛选"经验"（设定），选择能被选定的药物靶点高概率激活的化合物。这个筛选系统是基于基因工程酵母的。这使得"夏娃"能排除对细胞有毒的物质，并选择能阻断寄生虫蛋白质的，同时对人蛋白质毫发无损的化合物。筛选出的化合物随后自动地被工程化修改，以便于更快，比定制测定法中比标准更便宜地方式产生。"夏娃"同时使用多种类型的测定法和更有效地利用检查设施，"夏娃"这些优点增加了一定预算内发现新潜在药物的概率。

研发团队将"夏娃"的首秀用于热带疾病药物的搜索。他表示被忽视的热带病是人类的祸害，每年杀死数百万人，我们知道是什么原因导致这些疾病。在理论上我们可以研发，使用小分子药物攻击致病的寄生虫，但实际上研发成本和药物发现的速度，经济回报等因素使得制药业对此没有兴趣。

为了测试这种方法的可行性，研究人员针对如疟疾，南美锥虫病和血吸虫病热带寄生虫病，对约1500种临床批准药物的关键分子进行检测。通过检测，"夏娃"确认一种先前已认定作为抗癌药物的化合物能抑制疟原虫治病的关键分子，DHFR。目前常规用于预防疟疾的药物通常是能抑制DHFR的药物。考虑到现在尽管付出大量的努力，仍然没有人能找到一种新的抗疟药，并能够通过临床试验。所以"夏娃"的发现不仅仅展示的是一种新的方法，更可能为抗疟药的更新带来新贡献。

"夏娃"的工作极大降低了药物筛选的成本，不确定性和时间，并且将可能改善数以百万计世界各地的人们生活。

原始出处：

Artificially intelligent robot scientist 'Eve' could boost search for new drugs

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2015-02-16 Johnny1989

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2015-02-16 Johnny1989

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2015-02-08 lqvr

#研发#

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2015-02-08 xue8602

#机器人#

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2015-02-08 ms6279672939590805

#机器#

44 0
[GetPortalCommentsPageByObjectIdResponse(id=16056, encodeId=f0d116056d6, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cce01615276, createdName=Johnny1989, createdTime=Mon Feb 16 15:34:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16036, encodeId=eb34160361a, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cce01615276, createdName=Johnny1989, createdTime=Mon Feb 16 15:30:00 CST 2015, time=2015-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1299857, encodeId=ac2c129985e57, content=<a href='/topic/show?id=ed5ee332423' target=_blank style='color:#2F92EE;'>#研发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73324, encryptionId=ed5ee332423, topicName=研发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aea0290, createdName=lqvr, createdTime=Sun Feb 08 05:45:00 CST 2015, time=2015-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321855, encodeId=181a132185584, content=<a href='/topic/show?id=890c611854e' target=_blank style='color:#2F92EE;'>#机器人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61185, encryptionId=890c611854e, topicName=机器人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Sun Feb 08 05:45:00 CST 2015, time=2015-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582905, encodeId=ee82158290533, content=<a href='/topic/show?id=f6e1611840d' target=_blank style='color:#2F92EE;'>#机器#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61184, encryptionId=f6e1611840d, topicName=机器)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13dc16973127, createdName=ms6279672939590805, createdTime=Sun Feb 08 05:45:00 CST 2015, time=2015-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15222, encodeId=077a152228b, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=167, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9efb91372, createdName=huahua1, createdTime=Fri Feb 06 20:59:00 CST 2015, time=2015-02-06, status=1, ipAttribution=)]
2015-02-06 huahua1

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