Heart:老年女性腹主动脉钙化、心肌肌钙蛋白I和动脉粥样硬化血管疾病死亡率的关系

2022-01-03 网络 网络

较高的AAC和hs-cTnI水平升高与较高的ASVD死亡率和全因死亡率风险相关,且相互独立。通过中度至广泛的AAC和hs-cTnI是否升高进行分层,确定了非常高风险的女性。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,该研究旨在评估动脉粥样硬化血管疾病(ASVD)的两种廉价检查指标:腹主动脉钙化(AAC)和高敏心肌肌钙蛋白I(hs-cTnI)是否为老年妇女的10年ASVD死亡率和全因死亡率风险提供了额外的信息。

在2003年至2013年期间,研究人员对908名无ASVD(≥75岁)的社区居民进行了随访。2003年获得了受试者的AAC和血浆hs-cTnI测量值。研究人员使用半定量方法(AAC24)在侧脊柱图像上评估了AAC。关联的健康记录被用于死亡率结局分析。

受试者平均年龄±SD为79.9±2.6岁。276名(30.4%)女性在随访期间死亡,包括138名(15.2%)与ASVD相关的死亡。AAC24和hs-cTnI与ASVD和全因死亡率独立相关(p<0.001)。

该队列被分为四组:(1)低AAC24(AAC24:0或1)和hs-cTnI<中值(n=163,参考组),(2)中等广泛的AAC24(AAC24:>1)和hs-cTnI<中值(n=280),(3)低AAC24和hs-cTnI≥中值(n=148)和(4)中度广泛的AAC24和hs-cTnI≥中值(n=317)。与参考组相比,ASVD死亡率的相对风险(HR(95%CI))逐步增加,分别为2.39(1.05至5.46)、3.18(1.35至7.79)和5.38(2.44至11.85)。在全因死亡率方面观察到类似的关联,分别为1.58(0.99-2.52)、2.38(1.46-3.89)和3.02(1.93-4.72)(所有p<0.05)。

由此可见,较高的AAC和hs-cTnI水平升高与较高的ASVD死亡率和全因死亡率风险相关,且相互独立。通过中度至广泛的AAC和hs-cTnI是否升高进行分层,确定了非常高风险的女性。需要进一步研究调查组合因素是否可以改善风险预测。

原始出处:

Ryan Teh.et al.Abdominal aortic calcification, cardiac troponin I and atherosclerotic vascular disease mortality in older women.heart.2021.https://heart.bmj.com/content/early/2021/12/23/heartjnl-2021-319879

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createdTime=Wed Jan 05 06:30:08 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1180302, encodeId=ee1911803028b, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23d75606352, createdName=ms7000002132840773, createdTime=Tue Jan 04 09:29:39 CST 2022, time=2022-01-04, status=1, ipAttribution=)]
    2022-01-05 zhaojie88
  5. 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  6. 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  7. 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  8. 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    2022-01-05 slcumt
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    2022-01-04 ms7000002132840773

    学习学习

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