Hepatol Int:肝硬化的死亡率高于5种主要癌症的死亡率

2018-03-15 MedSci MedSci原创

肝硬化的死亡率高于5种主要癌症(肺癌、结直肠癌、胃癌、肝癌、乳腺癌)的死亡率

众所周知,肝硬化患者的生存率较低,肝硬化与其他致命疾病的关系的评估将有助于设计适当的健康干预措施。近日,发表在Hepatol Int上的一篇文章表明,肝硬化的死亡率高于5种主要癌症(肺癌结直肠癌胃癌、肝癌、乳腺癌)的死亡率。

此研究使用2002年至2010年,国家健康保险服务国家样本组(NHIS-NSC)的数据。研究共纳入韩国46,605,433人的1025340个有代表性的样本数据。

在8年之间,800/2609的肝硬化患者发生死亡,1316/4852的癌症患者,发生死亡。将肝硬化和五种主要癌症的死亡率进行评估时,肝硬化患者的相对死亡率更高[在对年龄、性别、居住地、保险类型、保费水平、并发症进行调整后,危险比为1.47 (95% CI 1.28-1.67)]。采用敏感性分析,排除即有肝硬化又存在5种主要癌症之一的患者,研究结果依然表明肝硬化的死亡率高于5种主要癌症的死亡率[危险比:1.27 (95% CI 1.10-1.47)]。此外,当研究将肝硬化患者局限于失代偿性肝硬化患者时,失代偿性肝硬化的相对死亡率甚至更高于五种癌症的死亡率[危险比1.82 (95%CI 1.51-2.20)]。

原始出处


Chung W; Jo C; Chung WJ; et al. Liver cirrhosis and cancer: comparison of mortality. Hepatol Int, 2018, 2018 Mar 1. doi: 10.1007/s12072-018-9850-5.

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    2018-03-17 gwc384
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    2018-03-16 changjiu

    学习一下谢谢

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    2018-03-16 海之蓝

    学习

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