Thorax：肺癌术后早期死亡率与年龄相关

　　英国学者的一项研究显示，年龄是预测术后早期死亡率的最重要因子。相关论文2013年5月17日在线发表于《喉》杂志 。。

　　该研究纳入在2004-2010年期间手术的10991例非小细胞肺癌（NSCLC）患者的资料，了解其术后30-90天的死亡率。我们量化了术后早期死亡率的预测因子，并使用这些结果设计出一个得分来预测术后90天的死亡风险。

　　结果显示，3%（334例）的患者在术后30天内死亡，5.9%（647例）在术后90天内死亡。早期术后死亡与年龄显著相关（OR=1.46；95%CI=1.07-1.98）；还与身体机能状态（PS）（OR=2.40；95%CI=1.68-3.41）、肺功能、分期和手术类型显著相关。

Early mortality after surgical resection for lung cancer: an analysis of the English National Lung cancer audit.
INTRODUCTION
For appropriately staged non-small cell lung cancer (NSCLC) surgical resection can dramatically improve survival, but some may not be offered this treatment because of concerns about perioperative mortality.
METHODS
We used data from the National Lung Cancer Audit (NLCA) to determine the proportions of English patients who died within 30 and 90 days after surgery for NSCLC. We quantified the predictors of early postoperative death and using these results devised a score to predict risk of death within 90 days of surgery.
RESULTS
We analysed data on 10 991 patients operated on between 2004 and 2010. Three per cent (334) of patients died within 30 days of their procedure and 5.9% (647) within 90 days. Age was strongly associated with early postoperative death (adjusted OR within 90 days for 80-84 years vs 70-74 years: 1.46, 95% CI 1.07 to 1.98); significant associations were also observed with performance status (PS) (adjusted OR within 90 days for PS 2 vs PS 0: 2.40, 95% CI 1.68 to 3.41), as well as lung function, stage and procedure type.
CONCLUSIONS
Our results show that age is the most important predictor of death within both of these early postoperative periods. We used the data in the NLCA to develop a predictive score, based on an English population and specific to lung cancer surgery, which estimates risk of death within 90 days; this score should be tested in future cohorts.