J Am Acad Dermatol:住院儿童中,银屑病与多种心血管并发症风险增高相关

2017-10-31 MedSci MedSci原创

背景:银屑病已被证明与成年人的心血管疾病有关。但银屑病对儿童心血管风险的影响却鲜为人知。目的:本研究旨在确定儿童银屑病与心血管并发症是否存在相关性。方法:本研究的数据来自2002-2012年韩国全国住院患者样本,研究人员对其中4884448例年龄在0-17岁的住院儿童的数据进行了分析。研究人员建立了双变量和多变量的logistic回归模型来计算银屑病儿童患心血管并发症的几率。结果:在多元logis

背景:银屑病已被证明与成年人的心血管疾病有关。但银屑病对儿童血管风险的影响却鲜为人知。

目的:本研究旨在确定儿童银屑病与心血管并发症是否存在相关性。

方法:本研究的数据来自2002-2012年韩国全国住院患者样本,研究人员对其中4884448例年龄在0-17岁的住院儿童的数据进行了分析。研究人员建立了双变量和多变量的logistic回归模型来计算银屑病儿童患心血管并发症的几率。

结果:在多元logistic回归模型中,调整年龄、性别、种族/民族后,儿童银屑病与10种心血管并发症中的5种显著相关(调整后的比值比[ 95%可信区间]),具体为肥胖(3.15 [ 2.46-4.05 ])、高血压(2.63 [ 1.93-3.59 ])、糖尿病(2.90 [ 1.90-4.42 ])、心律失常(1.39 [ 1.02-1.88 ])和心脏瓣膜病(1.90 [ 1.07-3.37 ])。在黑人和西班牙裔儿童,以及年龄中0-9岁的儿童中,发生心血管危险因素的几率最高,但无性别差异。

局限性:这项研究的数据仅包括住院儿童,无法评估银屑病治疗或家族史对心血管风险的影响。

结论:住院儿童中,儿童银屑病与更高几率的多种心血管并发症相关。未来需要确定儿童银屑病降低多余心血管风险的策略。

原始出处:

Kwa L, Kwa MC,et al.Cardiovascular comorbidities of pediatric psoriasis among hospitalized children in the United States.J Am Acad Dermatol. 2017 Sep 27. pii: S0190-9622(17)32267-3. doi: 10.1016/j.jaad.2017.08.034. [Epub ahead of print]

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    2018-09-30 丁鹏鹏
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    2017-12-09 lishizhe
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    2017-11-02 liuxiaona
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    2017-11-02 liuxiaona
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    2017-11-01 飛歌

    学习了很有用不错

    0

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J Am Acad Dermatol: 银屑病和化脓性汗腺炎,谁对患者的生活质量影响更大?

背景:银屑病(Psoriasis)和化脓性汗腺炎(hidradenitis suppurativa,HS)都具有明显的临床特征,但没有研究直接地比较中度至重度的这两类患者的健康相关的生活质量(HRQoL)。目的:本研究旨在确定哪些疾病与更严重的HRQOL损害有关。方法:研究人员在5个临床试验中计算并比较了HS和银屑病患者基线时测量得到的HRQOL的加权算术平均数,这5个临床试验分别为:疼痛视觉模拟

Br J Dermatol:Ixekizumab治疗银屑病起效迅速且疗效较优

背景:Ixekizumab,是一个高亲和力的单克隆抗体,它能选择性地针对白细胞介素(IL)- 17A。2016年,FDA批准Taltz(ixekizumab,80mg/mL)注射液用于适合系统治疗(systemic therapy,即全身疗治)或光疗(phototherapy)的中度至重度斑块型银屑病(plaque psoriasis)成人患者的治疗。Taltz不能用于对活性药物成分ixekizu

中国银屑病患者超600万!治疗需破除3个误区

每年的10月29日是世界银屑病日,今年的主题是认识银屑病。在世界银屑病日前夕,来听听中华医学会皮肤性病学分会前任主委、北京大学人民医院皮肤科主任张建中教授介绍关于银屑病的相关情况。

“治好”银屑病别犯这3个误区!

皮肤红斑、瘙痒、皮屑增多让银屑病患者苦不堪言,甚至头发轻轻一甩,头皮屑就如片片白雪一样飘落。每年的10月29日是世界银屑病日,今年世界银屑病日的主题是”全面认识银屑病”。在世界银屑病日前夕,来听听中华医学会皮肤性病学分会前任主委、北京大学人民医院皮肤科主任张建中教授介绍银屑病的点点滴滴。