Pre Oncology:科学家找到成功“饿死”癌细胞的天然化合物

2017-06-19 Heather_z727 来宝网

德克萨斯大学奥斯汀分校的研究人员发现了一种有潜力的天然化合物,这种化合物可以成功“饿死”前列腺癌癌细胞,使肿瘤缩小。这种化合物存在于姜黄,红葡萄皮和苹果皮中,如果将这三者组合,效果似乎更加强大。完整的研究报告发表于《精密肿瘤学》杂志上。



姜黄,红葡萄和苹果中的化合物可以有效“饿死”癌细胞】德克萨斯大学奥斯汀分校的研究人员发现了一种有潜力的天然化合物,这种化合物可以成功“饿死”前列腺癌癌细胞,使肿瘤缩小。这种化合物存在于姜黄,红葡萄皮和苹果皮中,如果将这三者组合,效果似乎更加强大。完整的研究报告发表于《精密肿瘤学》杂志上。

根据美国癌症协会的数据显示,前列腺癌是最常见的男性癌症,每年约有161360例新增病例,死于前列腺癌的人数也约有26730人。

在之前的研究中,已经确定了一些可以降低前列腺癌风险的化合物,特别是在植物性食物中尤为常见。

在此次研究中,科学家们使用高通量筛选技术测试了142天然化合物,目的是确定那些化合物可以有效阻止前列腺癌细胞的生长。在试验过程中,研究人员确定了三种最有效阻止前列腺癌细胞生长的化合物,它们分别存在于姜黄素,(明亮的黄色化合物),乌索酸(苹果皮)和白藜芦醇(红葡萄和浆果)。

研究人员发现,乌索酸结合姜黄素或者白藜芦醇的天然化合物,成功阻止前列腺癌中的谷氨酰胺,减缓了肿瘤的生长。谷氨酰胺是一种氨基酸,它是前列腺癌细胞生长所需的关键成分,因此,有效防止其吸收就可以使癌细胞最终走向死亡。更重要的是,因为乌索酸,姜黄素和白藜芦醇都是天然化合物,他们不会造成其他的不良影响。

原始出处:

Alessia Lodi, Achinto Saha, Xiyuan Lu, et al. Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism. npj Precision Oncology 1, Article number: 18 (2017). doi:10.1038/s41698-017-0024-z.

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    2018-01-03 minlingfeng
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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcOAGL4WZUXZ90HsGwWFm3tKp8SHX6q24lRGWYzHaN0N66JJAvpzmYgc6veQ81xTmTrvDMaNeGa0JKmnyFYuj2R/0, createdBy=bd911692766, createdName=fztmed, createdTime=Tue Jun 20 08:59:12 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-23 jet747

    哈哈,饿死肿瘤是研究的热点啊!

    0

  5. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcOAGL4WZUXZ90HsGwWFm3tKp8SHX6q24lRGWYzHaN0N66JJAvpzmYgc6veQ81xTmTrvDMaNeGa0JKmnyFYuj2R/0, createdBy=bd911692766, createdName=fztmed, createdTime=Tue Jun 20 08:59:12 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-22 虈亣靌

    值得推荐一下

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcOAGL4WZUXZ90HsGwWFm3tKp8SHX6q24lRGWYzHaN0N66JJAvpzmYgc6veQ81xTmTrvDMaNeGa0JKmnyFYuj2R/0, createdBy=bd911692766, createdName=fztmed, createdTime=Tue Jun 20 08:59:12 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-21 luominglian113

    学习了,谢谢分享

    0

  7. 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    2017-06-21 往日如昨

    学习了谢谢分享

    0

  8. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcOAGL4WZUXZ90HsGwWFm3tKp8SHX6q24lRGWYzHaN0N66JJAvpzmYgc6veQ81xTmTrvDMaNeGa0JKmnyFYuj2R/0, createdBy=bd911692766, createdName=fztmed, createdTime=Tue Jun 20 08:59:12 CST 2017, time=2017-06-20, status=1, ipAttribution=)]
    2017-06-21 yxch36
  9. 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    2017-06-20 fztmed

    太厉害了,伟大的发现

    0

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人体拥有大量的微生物群,影响癌症的易感性,其影响的部分原因是:其代谢能力巨大,对免疫细胞的功能产生重要影响。微生物病原体在15%〜20%的癌症病例中驱动肿瘤发生。通过使用宏基因组测序的微生物组研究,研究者们认为存在更多数量的恶性肿瘤与共生微生物群(dysbiosis)的组合变化相关。