Arch Gynecol Obstet:氨氯地平能改善PCOS患者的卵巢血流,增加受孕几率

2020-10-02 MedSci原创 MedSci原创

本研究旨在探究氨氯地平是否能增加排卵前卵泡血流量,从而增强排卵能力,为PCOS女性创造更好的受孕机会,研究结果已在线发表于Arch Gynecol Obstet。

本研究旨在探究氨氯地平是否能增加排卵前卵泡血流量,从而增强排卵能力,为PCOS女性创造更好的受孕机会,研究结果已在线发表于Arch Gynecol Obstet。

 

研究共筛选了165名女性,其中124名女性符合条件,将其平均随机分为62名接受枸橼酸氯米芬和氨氯地平,62名接受枸橼酸氯米芬和安慰剂。主要结果是通过药物给药,通过卵巢动脉的颜色和功率多普勒脉动指数研究氨氯地平是否可以改善排卵前卵泡血流量。次要结果是子宫内膜厚度和临床妊娠情况。

 

结果显示,与安慰剂组相比,氨氯地平组卵巢动脉脉动指数均值显著降低(分别为1.36和1.82,P值为0.002)。两组所有女性在检测到成熟卵泡当日的平均子宫内膜厚度,氨氯地平组明显高于安慰剂组(分别为8.99和7.0,P值为0.003),氨氯地平组临床妊娠率较安慰剂组由11%上升至37%。

 

综上所述,该研究结果表明,氨氯地平能改善卵巢血流,增加受孕几率。

 

原始出处:

 

Haitham A TorkyAtef Shata, et al., Effect of amlodipine on blood flow of preovulatory follicle in women with clomiphene resistant polycystic ovaries: a randomized controlled trial. Arch Gynecol Obstet. 2020 Mar;301(3):845-850. doi: 10.1007/s00404-020-05471-z. 

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    2021-02-06 楚秀娟
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    2021-06-21 zhouqu_8
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    2020-10-06 1581f8c42cm

    多学习

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    2020-10-02 ms7000000127904807

    学习使人进步

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