Sci Rep：为什么俄罗斯肺结核更具有传染性？

2016-08-27 佚名生物谷

俄罗斯研究人员进行了一项大规模的结核分枝杆菌菌株的蛋白质和基因组分析，这在俄罗斯和前苏联国家中比较常见。论文详细的结果已经发表在《科学报告》上。直到20世纪时肺结核都被认为是不治之症，尽管在早期阶段有新开发的治疗方法，但其死亡率仍然很高。包括俄罗斯在内的22个国家该病的感染率是世界其它国家的四倍。重要的是“肺结核”这个术语涵盖了广泛的细菌菌株引起的疾病。北京家族菌株基因型在北京首次被发现，

俄罗斯研究人员进行了一项大规模的结核分枝杆菌菌株的蛋白质和基因组分析，这在俄罗斯和前苏联国家中比较常见。论文详细的结果已经发表在《科学报告》上。

直到20世纪时肺结核都被认为是不治之症，尽管在早期阶段有新开发的治疗方法，但其死亡率仍然很高。包括俄罗斯在内的22个国家该病的感染率是世界其它国家的四倍。重要的是“肺结核”这个术语涵盖了广泛的细菌菌株引起的疾病。北京家族菌株基因型在北京首次被发现，在俄罗斯比较流行，每年大约有150，000人感染此病。为了研究这一毒株，科学家将北京 B0/W148产出的蛋白质与对照组进行比较。研究人员分离了细菌蛋白质酶并裂解成小片段肽断，使用质谱精确测量它们的质量和相对丰度。

分析数据之后，科学家们知道了每个菌株中有多少蛋白质。相比对照组来说，北京B0/W148菌株中有266个蛋白质是不同的，实验组中有57个蛋白质完全不存在，有17个蛋白质是唯一存在，而其它蛋白在数量上是不同的。分析北京B0 / W148菌株与不同蛋白质相关功能显示，有更多的蛋白质生产长链脂肪酸，有些蛋白质会破坏它们。细菌利用这些酸产生霉菌酸，霉菌酸在细菌细胞膜中能使自己蜡质化，这就是为什么分枝杆菌可以在巨噬细胞(特殊的人类细胞，破坏外来物质)中生存，甚至可以繁殖。

通常情况下，如果一种细菌被巨噬细胞吞噬它就已经死了。然而，结核分枝杆菌菌株已经进化到巨噬细胞内繁殖，这样做就可以使它们躲避免疫系统的攻击。霉菌酸不仅能保护细菌，而且在合成物质中也发挥了至关重要的作用，能够抑制巨噬细胞的免疫功能。这些新发现的脂质代谢的特性可以成功的解释北京B0 / W148菌株与其他结核分枝杆菌的相关性。

原始出处：

Bespyatykh J, Shitikov E, Butenko I, Altukhov I, Alexeev D, Mokrousov I, Dogonadze M, Zhuravlev V, Yablonsky P, Ilina E, Govorun V. Proteome analysis of the Mycobacterium tuberculosis Beijing B0/W148 cluster. Sci Rep. 2016 Jun 30;6:28985. doi: 10.1038/srep28985.

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2017-04-15 xzw113

#传染性#

0 0
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2016-09-18 1e10c84am36(暂无匿称)

不错哦继续关注

55 0
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encodeId=31a010629351, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Sun Aug 28 12:36:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
2016-09-05 李东泽

很好，不错，以后会多学习

65 0
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encodeId=31a010629351, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Sun Aug 28 12:36:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
2016-09-03 李东泽

很好，不错，以后会多学习

54 0
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 08:17:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107565, encodeId=b71a10e565a4, content=这篇咨询不错哦，值得学习，对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Aug 30 15:48:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253998, encodeId=01191253998e2, content=<a href='/topic/show?id=f30ae86297d' target=_blank 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encodeId=31a010629351, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Sun Aug 28 12:36:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
2016-08-30 李东泽

这篇咨询不错哦，值得学习，对于临床工作和科研思路都很有帮助。

69 0
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 08:17:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107565, encodeId=b71a10e565a4, content=这篇咨询不错哦，值得学习，对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Aug 30 15:48:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253998, encodeId=01191253998e2, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Mon Aug 29 14:47:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106716, encodeId=3664106e16fe, content=学习啦，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Mon Aug 29 10:01:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), 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encodeId=31a010629351, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Sun Aug 28 12:36:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
2016-08-29 huhuaidong387

#结核#

23 0
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 08:17:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107565, encodeId=b71a10e565a4, content=这篇咨询不错哦，值得学习，对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Aug 30 15:48:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253998, encodeId=01191253998e2, content=<a href='/topic/show?id=f30ae86297d' target=_blank 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encodeId=31a010629351, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Sun Aug 28 12:36:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
2016-08-29 医路开来

学习啦，谢谢分享

60 0
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encodeId=31a010629351, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Sun Aug 28 12:36:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
2016-08-29 zibozhouping

变异体，新理念，值得重视！值得学习。

25 0
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 08:17:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107565, encodeId=b71a10e565a4, content=这篇咨询不错哦，值得学习，对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Aug 30 15:48:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253998, encodeId=01191253998e2, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Mon Aug 29 14:47:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106716, encodeId=3664106e16fe, content=学习啦，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Mon Aug 29 10:01:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), 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encodeId=31a010629351, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Sun Aug 28 12:36:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
2016-08-28 1dd8c52fm63(暂无匿称)

学习学习！

24 0
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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 08:17:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=107565, encodeId=b71a10e565a4, content=这篇咨询不错哦，值得学习，对于临床工作和科研思路都很有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Tue Aug 30 15:48:00 CST 2016, time=2016-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253998, encodeId=01191253998e2, content=<a href='/topic/show?id=f30ae86297d' target=_blank style='color:#2F92EE;'>#结核#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78629, encryptionId=f30ae86297d, topicName=结核)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=huhuaidong387, createdTime=Mon Aug 29 14:47:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106716, encodeId=3664106e16fe, content=学习啦，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Mon Aug 29 10:01:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106638, encodeId=004f106638f3, content=变异体，新理念，值得重视！值得学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Mon Aug 29 07:55:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106355, encodeId=e8fa106355d3, content=学习学习！, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Aug 28 16:03:00 CST 2016, time=2016-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106293, encodeId=31a010629351, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Sun Aug 28 12:36:00 CST 2016, time=2016-08-28, status=1, ipAttribution=)]
2016-08-28 Guoxj3234

学习起来

25 0