J Rheumatol:手部骨关节炎患病率、发病率和进展与BMI、吸烟、饮酒的关系

2017-07-17 xiangting MedSci原创

超重/肥胖与手部OA无关。在吸烟和手部OA之间观察到相反结果,提示缺乏关联。

这项研究旨在估计超重/肥胖、吸烟和酒精与手部骨关节炎(OA)的患病率和纵向影像学改变的相关程度。

纳入骨关节炎倡议的参与者(n = 1232),其中994例有4年的随访数据。在偶发手部OA的分析中,只纳入基线时没有手部OA的参与者(n = 406)。暴露变量是超重/肥胖[体质量指数(BMI),腰围],吸烟(目前/以前,吸烟包数每年)和饮酒(次数/周)。使用线性和logistic回归分析,分析了基线暴露变量与影像学手部OA严重程度,侵蚀性手部OA,手部OA发病率和影像学变化之间的可能关联。分析根据年龄、性别和教育程度进行调整。

超重或肥胖均与手部OA无关。在横断面分析中,目前吸烟与手部OA较少相关,而纵向分析显示,目前吸烟者的手部OA的发病几率较高(OR 2.20,95%CI 1.02-4.77)。中度饮酒与基线时Kellgren-Lawrence总得分较高(1-3次/周:1.55,95%CI 0.43-2.67)和4年随访期间总得分升高有关(4-7次/周:0.33,95%CI 0.01-0.64)。中度饮酒(1-7次/周)与侵蚀性手部OA几率两倍以上相关,并有统计学意义。根据BMI的额外调整结论相似。

超重/肥胖与手部OA无关。在吸烟和手部OA之间观察到相反结果,提示缺乏关联。中度饮酒与手部OA严重程度,影像学改变和侵蚀性手部OA有关,仍需要进一步的研究。

原始出处:

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    2017-10-27 lisa438
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    2017-07-19 lmm397
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    2017-07-17 桂杉

    每天都能学到不一样的知识

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