Nat Genet：男性易患癌，Y染色体之罪

2014-08-14 佚名手牵手博客站

性别非特异性癌症在男性人群中的患病率和死亡率更高，但其深层的原因却并不明确。最近，一项在1000多位成年男性中开展的研究显示，外周血细胞中的Y染色体镶嵌式缺失（loss of chromosome Y，LOY）也许是造成男性更高癌症风险和死亡率的原因。相关文献发表于 Nature Genetic。Lars Forsberg及其同事对Uppsala Longitudinal Study of Adu

性别非特异性癌症在男性人群中的患病率和死亡率更高，但其深层的原因却并不明确。最近，一项在1000多位成年男性中开展的研究显示，外周血细胞中的Y染色体镶嵌式缺失（loss of chromosome Y，LOY）也许是造成男性更高癌症风险和死亡率的原因。相关文献发表于 Nature Genetic。

Lars Forsberg及其同事对Uppsala Longitudinal Study of Adult Men男性试验受试者（70.7岁-83.6岁）的外周血DNA拷贝数变量进行了分析。有趣的是，他们发现最常见的共享基因变异是LOY。个体血细胞之间的LOY比例差异很大，且该比例随着患者的年龄增长而急剧增长。

研究人员在982位受试者中检测了镶嵌式LOY对患者存活率的影响。所有的受试者在入组时都为非癌症患者。在中位随访8.7年后，那些有LOY男性比无LOY男性的存活时间平均短了5.5年，而且其非血液癌症相关死亡的风险也更高。研究过程中，无受试者发展为血癌患者。类似的研究结果同样在另外488位男性受试者（来自 Prospective Investigation of the Vasculature in Uppsala Seniors Study）中被观察到。

该项研究提示，Y染色体在癌症发病中具有特殊的作用，但其作用机制仍不明确。研究人员还将开展更深层的探索，来了解血液中LOY对癌症的预测程度。

原始出处：

Forsberg LA1, Rasi C1, Malmqvist N2, Davies H1, Pasupulati S1, Pakalapati G1, Sandgren J3, de Ståhl TD3, Zaghlool A1, Giedraitis V4, Lannfelt L4, Score J5, Cross NC5, Absher D6, Janson ET7, Lindgren CM8, Morris AP9, Ingelsson E10, Lind L7, Dumanski JP1.Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer.Nat Genet. 2014 Jun;46(6):624-8. doi: 10.1038/ng.2966. Epub 2014 Apr 28.

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2015-07-04 liye789132251

#Nat#

23 0
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2014-10-26 江川靖瑶

#Genet#

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2015-07-29 cy0324

#Gene#

24 0
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2014-11-10 lhl1860

是不是我太菜了？我怎么感觉这个结果不是很困难？国内也能开展吧？

135 0
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2015-07-27 canlab

#NET#

34 0
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2014-08-16 新生儿张玉军

#染色体#

24 0
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2014-08-16 周虎

#Y染色体#

32 0
[GetPortalCommentsPageByObjectIdResponse(id=1880231, encodeId=f82b18802317c, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat Jul 04 03:20:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685964, encodeId=e652168596483, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Sun Oct 26 22:20:00 CST 2014, time=2014-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048614, encodeId=22c4204861406, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Wed Jul 29 15:20:00 CST 2015, time=2015-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=12463, encodeId=aedc1246350, content=是不是我太菜了？我怎么感觉这个结果不是很困难？国内也能开展吧？, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb5599428, createdName=lhl1860, createdTime=Mon Nov 10 12:32:00 CST 2014, time=2014-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1733710, encodeId=19141e33710b4, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Jul 27 06:20:00 CST 2015, time=2015-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331595, encodeId=907e1331595af, content=<a href='/topic/show?id=d85a6181e4d' target=_blank style='color:#2F92EE;'>#染色体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61817, encryptionId=d85a6181e4d, topicName=染色体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Sat Aug 16 00:20:00 CST 2014, time=2014-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538839, encodeId=071015388393d, content=<a href='/topic/show?id=9f5a189918d' target=_blank style='color:#2F92EE;'>#Y染色体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18991, encryptionId=9f5a189918d, topicName=Y染色体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1fc213064778, createdName=周虎, createdTime=Sat Aug 16 00:20:00 CST 2014, time=2014-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601341, encodeId=c53916013413a, content=<a href='/topic/show?id=5baa5299111' target=_blank style='color:#2F92EE;'>#患癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52991, encryptionId=5baa5299111, topicName=患癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=888f18872716, createdName=lq0307, createdTime=Sat Aug 16 00:20:00 CST 2014, time=2014-08-16, status=1, ipAttribution=)]
2014-08-16 lq0307

#患癌#

25 0

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