Circulation:感染性腹主动脉瘤患者是选择开放修复术还是腔内修复术?

2016-11-05 xing.T MedSci原创

在瑞典MAAAs患者的治疗模式已经发生了转变,EVAR成为了首选的治疗方式。EVAR能够改善患者短期生存率,而且并不伴有严重的感染或再手术相关并发症。

对于感染性腹主动脉瘤(MAAAs)患者到底是进行开放修复术还是接受腔内修复术(EVAR),目前并没有可靠的数据来进行比较。近日,心血管领域权威杂志Circulation上发表了一篇来自瑞典乌普萨拉大学医学部血管外科Karl Sörelius医生及其团队的研究文章,通过这个全国性的研究评估了MAAAs患者接受开放修复术和EVAR两种手术方式对患者预后的影响。

该研究纳入了在1994年至2014年期间,所有经瑞典血管注册中心确认的MAAAs患者,该研究的主要目的是评估接受开放修复术或EVAR的MAAAs患者术后生存率,次要目标是评估感染复发率、再手术率及手术治疗的时间趋势。研究者采用Kaplan Meier法和对数秩检验分析计算生存率,两组的危险因素差异通过倾向评分加权来校正,包括随着时间的推移在治疗和预后上的差异。

该研究共纳入了132例MAAAs患者,平均年龄为70岁(标准差9.2岁),有50例患者出现动脉瘤破裂。3个月生存率为86%(95%可信区间为80~92%),1年生存率为79%(95%可信区间为72-86%),5年生存率为59%(95%可信区间为50-68%)。


从2001年以后,MAAAs患者首选的手术方法从开放修复术变成了EVAR(接受EVAR的比例:1994-2000年为0%,2001-2007年为58%,2008-2014年为60%)。在62例(47%)进行开放修复术的患者中:7例进行主动脉切除和解剖外旁路术,50例进行原位重建,3例进行补片成形术,另有2例在术中死亡;在70例(53%)接受EVAR的患者中:55例患者进行标准治疗,8例患者进行开窗/分支EVAR,7例患者进行支架植入术,术中无死亡病例发生。

研究者发现相比于EVAR,接受开放修复术的患者3个月生存率较低(74% vs 96%,P<0.001),一年生存率也存在类似的趋势(73% vs 84%,P=0.054)。倾向评分加权分析证实了接受EVAR的患者早期疗效较好,研究者对接受开放修复术和EVAR的患者的中位随访时间分别为36个月和41个月,研究者发现两种治疗方式的长期生存率(5年生存率为60 vs 58%,P=0.771)、感染相关并发症(18 vs 24%,P=0.439)或再次手术(21% vs 24%,P=0.650)并无明显差异。

由此可见,在瑞典,MAAAs患者的治疗模式已经发生了转变,EVAR成为了首选的治疗方式。EVAR能够改善患者短期生存率,而且并不伴有严重的感染或再手术相关并发症。

原始出处:

Karl Sörelius,et al. Nationwide Study of the Treatment of Mycotic Abdominal Aortic Aneurysms Comparing Open and Endovascular Repair. Circulation. October 31, 2016  http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024021

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    2016-11-12 一个字-牛

    谢谢分享,学习了

    0

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    2016-11-10 laoli

    谢谢分享!学习了!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1928105, encodeId=6cab1928105dc, content=<a href='/topic/show?id=4a722e395ce' target=_blank style='color:#2F92EE;'>#修复术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27395, encryptionId=4a722e395ce, topicName=修复术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6779163, createdName=liuhuangbo, createdTime=Tue Nov 22 01:28:00 CST 2016, time=2016-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655359, encodeId=740a1655359f9, content=<a href='/topic/show?id=7c2853311ac' target=_blank style='color:#2F92EE;'>#感染性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53311, encryptionId=7c2853311ac, topicName=感染性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=583d24724321, createdName=charl1234575, createdTime=Fri Sep 15 07:28:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155235, encodeId=7f5b155235ea, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sat Nov 12 09:59:13 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154858, encodeId=84b91548588d, content=谢谢分享!学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Thu Nov 10 17:30:17 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415092, encodeId=f8ad1415092eb, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Mon Nov 07 06:28:00 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429011, encodeId=7f3314290119b, content=<a href='/topic/show?id=ee192321560' target=_blank style='color:#2F92EE;'>#主动脉瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23215, encryptionId=ee192321560, topicName=主动脉瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95e34160730, createdName=fengting4, createdTime=Mon Nov 07 06:28:00 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153685, encodeId=01111536855c, content=值得看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Sat Nov 05 22:11:59 CST 2016, time=2016-11-05, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1928105, encodeId=6cab1928105dc, content=<a href='/topic/show?id=4a722e395ce' target=_blank style='color:#2F92EE;'>#修复术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27395, encryptionId=4a722e395ce, topicName=修复术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6779163, createdName=liuhuangbo, createdTime=Tue Nov 22 01:28:00 CST 2016, time=2016-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655359, encodeId=740a1655359f9, content=<a href='/topic/show?id=7c2853311ac' target=_blank style='color:#2F92EE;'>#感染性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53311, encryptionId=7c2853311ac, topicName=感染性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=583d24724321, createdName=charl1234575, createdTime=Fri Sep 15 07:28:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155235, encodeId=7f5b155235ea, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sat Nov 12 09:59:13 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154858, encodeId=84b91548588d, content=谢谢分享!学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Thu Nov 10 17:30:17 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415092, encodeId=f8ad1415092eb, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Mon Nov 07 06:28:00 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429011, encodeId=7f3314290119b, content=<a href='/topic/show?id=ee192321560' target=_blank style='color:#2F92EE;'>#主动脉瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23215, encryptionId=ee192321560, topicName=主动脉瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95e34160730, createdName=fengting4, createdTime=Mon Nov 07 06:28:00 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153685, encodeId=01111536855c, content=值得看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Sat Nov 05 22:11:59 CST 2016, time=2016-11-05, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1928105, encodeId=6cab1928105dc, content=<a href='/topic/show?id=4a722e395ce' target=_blank style='color:#2F92EE;'>#修复术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27395, encryptionId=4a722e395ce, topicName=修复术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6779163, createdName=liuhuangbo, createdTime=Tue Nov 22 01:28:00 CST 2016, time=2016-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655359, encodeId=740a1655359f9, content=<a href='/topic/show?id=7c2853311ac' target=_blank style='color:#2F92EE;'>#感染性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53311, encryptionId=7c2853311ac, topicName=感染性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=583d24724321, createdName=charl1234575, createdTime=Fri Sep 15 07:28:00 CST 2017, time=2017-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155235, encodeId=7f5b155235ea, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Sat Nov 12 09:59:13 CST 2016, time=2016-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154858, encodeId=84b91548588d, content=谢谢分享!学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLC1BMzZWdMSPQWuib6BtQGicK8ygGBM6YakpfkRc67soFSuKbZr86enL1KggQZEZbgWSeicJibafmYfQ3AibicIHMwwicmDShfRFvvI38/0, createdBy=272a110164, createdName=laoli, createdTime=Thu Nov 10 17:30:17 CST 2016, time=2016-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415092, encodeId=f8ad1415092eb, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Mon Nov 07 06:28:00 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429011, encodeId=7f3314290119b, content=<a href='/topic/show?id=ee192321560' target=_blank style='color:#2F92EE;'>#主动脉瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23215, encryptionId=ee192321560, topicName=主动脉瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95e34160730, createdName=fengting4, createdTime=Mon Nov 07 06:28:00 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=153685, encodeId=01111536855c, content=值得看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0f261920920, createdName=上邪zyy, createdTime=Sat Nov 05 22:11:59 CST 2016, time=2016-11-05, status=1, ipAttribution=)]
    2016-11-05 上邪zyy

    值得看看

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