Eur Heart J-Card Img:左心室不对称性对无症状性主动脉瓣狭窄患者的预后意义!

2018-02-11 xing.T MedSci原创

由此可见,LV不对称性是未来无症状主动脉瓣狭窄患者需要进行AVR的独立预测因子。它对LV几何形态具有增量预测价值,并可能提供有用方法进行危险分层。

主动脉瓣狭窄患者左心室(LV)不对称较为常见,以LV局部肥厚的形式表现出来。近日,心血管领域权威杂志Eur Heart J-Card Img上发表了一篇研究文章,该研究旨在检验LV不对称性可以预测无症状主动脉瓣狭窄患者未来症状状态和主动脉瓣置换术(AVR)指征这一假设。

该研究共纳入了114名无症状性主动脉瓣狭窄患者(超声心动图筛查评估峰值速度>2.5m/s,左心室射血分数>50%)。根据之前的定义,研究人员通过多探头计算机断层成像评估LV不对称性和LV几何形状。通过电子健康记录进行随访,并使用Cox比例风险模型评估无事件生存情况。

随访中位时间为2.2年(四分位间距为1.6-3.6)。出现AVR指征的患者有46例(40%)。LV不对称患者进行AVR的风险是无LV不对称的患者的3倍(风险比:3.16; 95%可信区间:1.77-5.66; P<0.001)。多变量Cox分析显示LV不对称是未来需要进行AVR的一个预测因子(风险比:3.10; 95%可信区间:1.44-6.65; P=0.004),并且独立于LV几何形状、射流速度、瓣膜钙化和pro-BNP。

由此可见,LV不对称性是未来无症状主动脉瓣狭窄患者需要进行AVR的独立预测因子。它对LV几何形态具有增量预测价值,并可能提供有用方法进行危险分层。

原始出处:

Per Ejlstrup Sigvardsen,et al. Prognostic implications of left ventricular asymmetry in patients with asymptomatic aortic valve stenosis. Eur Heart J-Card Img. 2018. https://doi.org/10.1093/ehjci/jew339

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    2018-02-13 zhaojie88
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    2018-02-13 slcumt
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    2018-02-11 131****1460

    学习了受益匪浅

    0