J Hypertens:高血压患者蛋白尿两年变化情况和心肌梗死风险有何关系?

2017-07-07 xing.T MedSci原创

由此可见,蛋白尿与心肌梗死发生率增加有关,但如果使用蛋白尿的基线指标,则可能会低估这种相关性。蛋白尿,特别是持续性蛋白尿指标的变化更有可能反映MI的终生风险。

近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,该研究旨在评估蛋白尿变化是否与高血压患者心肌梗死(MI)发生率有关。

Kailuan研究是一项关于心血管危险因素和事件的前瞻性纵向队列研究。研究人员使用Cox回归模型计算了风险比和95%置信区间(CI)。

该研究纳入了24926例既往无MI的高血压患者(平均年龄为55.2±10.9岁),经过6.8年的平均随访后,382例(1.5%)患者发生MI。在调整了血脂异常、糖尿病和其他心血管危险因素后,基线水平有蛋白尿的参与者与基线时无蛋白尿的参与者相比,发生心肌梗死的风险高出60%(风险比为1.60,95%CI为1.12-2.29)。与没有蛋白尿的参与者相比,随访期间发生蛋白尿或持续性蛋白尿的个体发生MI的风险分别增加54%和141%(分别有风险比为1.54,95%CI为1.14-2.09,风险比为2.41,95%CI为1.59-3.66;所有P<0.05)。

由此可见,蛋白尿与心肌梗死发生率增加有关,但如果使用蛋白尿的基线指标,则可能会低估这种相关性。蛋白尿,特别是持续性蛋白尿指标的变化更有可能反映MI的终生风险。

原始出处:

Wang, Anxin.et al. Two-year changes in proteinuria and risk for myocardial infarction in patients with hypertension: a prospective cohort study.Journal of Hypertension. 2017. http://journals.lww.com/jhypertension/Abstract/publishahead/Two_year_changes_in_proteinuria_and_risk_for.97677.aspx

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    2017-08-01 feather89
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    2017-07-10 changjiu

    学习了,谢谢

    0

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    2017-07-08 王秀

    学习了,涨知识了!

    0

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    2017-07-08 忠诚向上

    好好的看看有进步

    0

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    2017-07-07 184****9840

    学习了谢谢分享

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