Arthritis Rheumatol：类风湿关节炎患者胰岛素抵抗增加

2015-01-04 生物谷生物谷

类风湿关节炎(RA)患者具有胰岛素抵抗(IR)升高现象，但这类患者胰岛素抵抗升高是不与动脉粥样硬化风险增加相关联，相关研究刊登在Arthritis & Rheumatology杂志上。哥伦比亚大学Jon T. Giles，MD和同事比较95例RA患者和统计学匹配的98名非RA对照组之间IR情况，使用HOMA胰岛素抵抗(HOMA-IR)指数评价胰岛素抵抗程度，HOMA-I

类风湿关节炎(RA)患者具有胰岛素抵抗(IR)升高现象，但这类患者胰岛素抵抗升高是不与动脉粥样硬化风险增加相关联，相关研究刊登在Arthritis & Rheumatology杂志上。

哥伦比亚大学Jon T. Giles，MD和同事比较95例RA患者和统计学匹配的98名非RA对照组之间IR情况，使用HOMA胰岛素抵抗(HOMA-IR)指数评价胰岛素抵抗程度，HOMA-IR即稳态模型胰岛素抵抗指数。

研究人员发现，平均HOMA-IR水平在RA组中高出31%，在对照组中，HOMA-IR和与C-反应蛋白和白细胞介素-6水平有关，但这种关联在RA组中较弱。

在那些类风湿性关节炎患者中，HOMA-IR升高与男性和女性的类风湿因子阳性相关，以及与妇女是否使用泼尼松相关。在平均3.2年的随访中，RA患者之间，基线和平均HOMA-IR都不与动脉粥样硬化风险增加相关。虽然RA的IR高于非RA，但更高水平的IR可能不会单独增加动脉粥样硬化风险。

原始出处：

Giles JT1, Danielides S, Szklo M, Post WS, Blumenthal RS, Petri M, Schreiner PJ, Budoff M, Detrano R, Bathon JM.Insulin resistance in rheumatoid arthritis: Disease related indicators and associations with the presence and progression of subclinical atherosclerosis.Arthritis Rheumatol. 2014 Dec 10. doi: 10.1002/art.38986. [Epub ahead of print]

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2015-01-29 ms6390871039024434

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2015-04-19 shenxlcyp

#类风湿关节炎患者#

29 0
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2015-08-31 baoya

#胰岛#

29 0
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2015-01-10 zczcz6655

很不错的文章

109 0
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2015-01-06 lmm397

#关节炎#

27 0
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2015-01-06 ms4964546379600229

#类风湿#

26 0
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2015-01-06 智智灵药

#ART#

0 0
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2015-01-06 xuruicheng

#风湿关节炎#

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