J Periodontol:非手术治疗可以有效减少LAP中Aa的JP2克隆表型

2017-08-27 MedSci MedSci原创

之前的研究已经表明,放线菌总核细胞(Aa)以及其白细胞高致毒性的JP2基因型与局限性侵袭性牙周炎(LAP)密切相关。这篇研究的目的是为了评估LAP个体在牙周治疗后是否存在JP2。

之前的研究已经表明,放线菌总核细胞(Aa)以及其白细胞高致毒性的JP2基因型与局限性侵袭性牙周炎(LAP)密切相关。这篇研究的目的是为了评估LAP个体在牙周治疗后是否存在JP2。研究选取了60名年龄在5-25岁之间罹患LAP的非裔美国人作为评估对象。在治疗前,检测患者的袋深(PD)、临床附着水平(CAL)、探诊出血情况(BoP)和菌斑指数,并且收集每名受试者LAP侧和健侧的龈下菌斑。对所有患者施以超声洁治、刮治和根面平整以及下处方(7天的阿莫西林及甲硝唑)。在治疗后的3、6和12个月,对受试者施以规律的维持治疗,并再次取样、进行评估。在治疗前后,采用PCR技术检测JP2基因型的存在与否。结果显示,在治疗前,LAP患侧的JP2序列检出率为75%,健侧为56.67%。在治疗后的3、6和12个月,患者的依从人数分别为40, 31和31名,患侧JP2的检出率分别降为17.5%, 6.45%和3.23% (P<0.001),而健侧分别降为2.5%, 3.23%和0% (P<0.001)。治疗后,疾病的临床指标也明显降低(p<0001)。另外,治疗后,JP2的存在与平均PD (p

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    2017-12-01 aids221
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    2018-01-06 LSJ122
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    2018-05-19 feather89
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237888, encodeId=531023e888d6, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Aug 28 07:00:32 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
  5. 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createdBy=06de33803044, createdName=LSJ122, createdTime=Sat Jan 06 02:42:00 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726676, encodeId=79791e266769e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat May 19 16:42:00 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290610, encodeId=d62a129061066, content=<a href='/topic/show?id=e86454454ea' target=_blank style='color:#2F92EE;'>#手术治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, 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content=学习受益匪浅.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Aug 28 11:54:12 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237912, encodeId=3a0923e912c6, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Aug 28 07:27:06 CST 2017, time=2017-08-28, 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  6. 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content=学习受益匪浅.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Aug 28 11:54:12 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237912, encodeId=3a0923e912c6, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Aug 28 07:27:06 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237888, encodeId=531023e888d6, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Aug 28 07:00:32 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2017-08-29 tastas
  7. 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content=学习受益匪浅.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Aug 28 11:54:12 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237912, encodeId=3a0923e912c6, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Aug 28 07:27:06 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237888, encodeId=531023e888d6, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Aug 28 07:00:32 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2017-08-28 圣艮山

    学习了不少事情!

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237888, encodeId=531023e888d6, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Aug 28 07:00:32 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2017-08-28 清风拂面

    学习受益匪浅.谢谢分享

    0

  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237888, encodeId=531023e888d6, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Aug 28 07:00:32 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2017-08-28 龙胆草

    学习谢谢分享

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=237888, encodeId=531023e888d6, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Aug 28 07:00:32 CST 2017, time=2017-08-28, status=1, ipAttribution=)]
    2017-08-28 惠映实验室

    学习了.谢谢.

    0

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