Allergy:加拿大、欧洲、南非和美国过敏性成年人对屋尘螨敏感情况的比较

2021-02-03 AlexYang MedSci原创

屋尘螨(HDM)是导致过敏性鼻炎和哮喘的主要原因,尽管迄今为止已经确定了30多种HDM来源的过敏原,但具体的治疗方法还没有考虑到患者当地的致敏特征。最近,有研究人员确定了生活在不同地理区域HDM过敏成

屋尘螨(HDM)是导致过敏性鼻炎和哮喘的主要原因,尽管迄今为止已经确定了30多种HDM来源的过敏原,但具体的治疗方法还没有考虑到患者当地的致敏特征。最近,有研究人员确定了生活在不同地理区域HDM过敏成人的HDM致敏模式,为开发有针对性的诊断和治疗工具提供信息

研究包括了来自加拿大、欧洲、南非和美国的685名HDM过敏受试者的血清样本,并进行了特异性IgE水平测试。研究结果表明,过敏模式和IgE水平存在显著的地域差异。在所有地区,主要的致敏原是第1组和第2组过敏原和Der p 23。Der p 23是一种常见的致敏原:64%的受试者对Der p 23有特异性IgE,2.3%的受试者对Der p 23有单一的致敏性。在南非,Der p 23是主要的HDM过敏原(86%的患病率),Der p 7达到了主要的过敏原状态(56%)。IgE对HDM的敏感性受哮喘状态、过敏原暴露水平、年龄、种族民族和吸烟状态的影响,但不受BMI影响。

基于地域和研究群体的HDM过敏原的IgE响应频率

最后,研究人员指出,在南非,Der p 7和Der p 23是主要的致敏原,不同地域的HDM过敏原敏感情况不同。在诊断和治疗HDM过敏患者时,应考虑到这种异质性

原始出处:

Varun Muddaluru, Rudolf Valenta , Susanne Vrtala et al. Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA. Allergy. Jan 2021

 

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    2021-02-05 膀胱癌
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    2021-02-05 hongbochen

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