可耐强抗生素的“超级细菌”,在美国再次现身!

2016-07-12 MedSci MedSci原创

美国研究人员11日说,美国发现第二例携带含基因MCR-1的“超级细菌”病例(首例是5月份报道:美国发现首例mcr-1多粘菌素耐药感染)(“超级细菌”现身美国,去年在中国首先发现! 可抵抗已知所有抗生素)。这个基因会使细菌对被称为抗生素中“最后一道防线”的多粘菌素产生耐药性。美国JMI实验室的研究人员在新一期美国《抗微生物制剂与化学疗法》期刊上报告说,在源于纽约一名患者的大肠杆菌中发现了MCR-1基

美国研究人员11日说,美国发现第二例携带含基因MCR-1的“超级细菌”病例(首例是5月份报道:美国发现首例mcr-1多粘菌素耐药感染)(“超级细菌”现身美国,去年在中国首先发现! 可抵抗已知所有抗生素)。这个基因会使细菌对被称为抗生素中“最后一道防线”的多粘菌素产生耐药性。

美国JMI实验室的研究人员在新一期美国《抗微生物制剂与化学疗法》期刊上报告说,在源于纽约一名患者的大肠杆菌中发现了MCR-1基因。不过,患者的详细情况没有公布。

此前,美国卫生官员于今年4月在宾夕法尼亚州发现一名49岁女性携带含有MCR-1基因的大肠杆菌。但纽约这名患者的样本于2015年提取,因此是目前所知美国最早的此类病例。

这个病例由一项名为“‘哨兵’抗菌剂监测项目”的国际计划发现,此计划检测了由亚太、拉美、欧洲和北美等地医院提供的1.3万多个大肠杆菌样本和7400多个肺炎杆菌样本。

结果显示,其中390个样本对多粘菌素具有耐药性,而这些样本中有19个携带MCR-1基因,它们来自上述4个地区的10个国家,相关病例中包括来自美国纽约的这名患者。

去年11月,中国首次报告在牲畜和人身上发现了带MCR-1基因的细菌。这种基因由细胞中的质粒携带,可以通过质粒而在不同细菌间传播。换句话说,该基因赋予细菌的耐药性可以传播给其他细菌,从而可能导致出现能对抗所有抗生素的细菌,引起极大关注。此后,欧盟与加拿大也相继发现了带有MCR-1基因的细菌(Lancet Infect Dis:人类最后一道细菌防线“粘菌素”耐药菌在中国出现)。

不过需要说明的是,美国两个病例感染的大肠杆菌仍然可用一些常用抗生素治疗,暂时还没有出现所有抗生素都失效的情况。美国JMI实验室的玛丽安娜·卡斯塔涅拉在一份声明中说,这种基因暂时还不太可能造成难以治疗的感染。

随着抗生素使用愈加频繁,细菌的耐药性问题也日益突显,目前抗菌能力强大的多粘菌素被视为抗生素“最后一道防线”。当青霉素、四环素等传统抗生素逐渐失效时,医护人员只能选择多粘菌素。鉴于农业和畜牧业中普遍使用多粘菌素,多位研究人员建议,应尽可能限制对多粘菌素的使用。

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1928312, encodeId=00561928312c4, content=<a href='/topic/show?id=440350165aa' target=_blank style='color:#2F92EE;'>#强抗生素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50165, encryptionId=440350165aa, topicName=强抗生素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Thu Dec 15 02:08:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141763, encodeId=27eb141e6366, content=文章很棒,继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Oct 08 08:38:17 CST 2016, time=2016-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321667, encodeId=0145132166e90, content=<a href='/topic/show?id=64049291048' target=_blank style='color:#2F92EE;'>#超级细菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92910, encryptionId=64049291048, topicName=超级细菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Thu Jul 14 06:08:00 CST 2016, time=2016-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92911, encodeId=b5e69291176, content=恐怕中国是抗药性最强的国家了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYZTmbW36JHpvHcnIog7VbWIQjibo1kwuH9obXRJJtqHn1hYHHLG0DpIMIBVFPhBBpQOJWDk1rbib2Y/0, createdBy=d27274268, createdName=sillywu, createdTime=Wed Jul 13 09:24:00 CST 2016, time=2016-07-13, status=1, ipAttribution=)]
    2016-10-08 1e10c84am36(暂无匿称)

    文章很棒,继续学习

    0

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1928312, encodeId=00561928312c4, content=<a href='/topic/show?id=440350165aa' target=_blank style='color:#2F92EE;'>#强抗生素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50165, encryptionId=440350165aa, topicName=强抗生素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Thu Dec 15 02:08:00 CST 2016, time=2016-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141763, encodeId=27eb141e6366, content=文章很棒,继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Oct 08 08:38:17 CST 2016, time=2016-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321667, encodeId=0145132166e90, content=<a href='/topic/show?id=64049291048' target=_blank style='color:#2F92EE;'>#超级细菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92910, encryptionId=64049291048, topicName=超级细菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea13490, createdName=xqptu, createdTime=Thu Jul 14 06:08:00 CST 2016, time=2016-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=92911, encodeId=b5e69291176, content=恐怕中国是抗药性最强的国家了, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYZTmbW36JHpvHcnIog7VbWIQjibo1kwuH9obXRJJtqHn1hYHHLG0DpIMIBVFPhBBpQOJWDk1rbib2Y/0, createdBy=d27274268, createdName=sillywu, createdTime=Wed Jul 13 09:24:00 CST 2016, time=2016-07-13, status=1, ipAttribution=)]
    2016-07-13 sillywu

    恐怕中国是抗药性最强的国家了

    0