Microbiome:王德华研究组揭示肠道菌群介导聚群行为节省能量的机制

2018-06-23 细胞 中国科学院动物所

会性动物(包括人类)具有群居生活的习性。群居生活的益处是能够提高动物获得食物的可能性、缓解压力、降低被捕食风险,以及提高自身和群体的适合度。聚群行为(Huddling)是社会性动物在恶劣环境下为提高自身适合度进化出的一种合作适应性行为。社会性体温调节(Social thermoregulation)假说认为聚群行为可以通过减少体表面积与体积之比率以减少热量散失而节约能量。王德华研究组发表文章从生理

社会性动物(包括人类)具有群居生活的习性。群居生活的益处是能够提高动物获得食物的可能性、缓解压力、降低被捕食风险,以及提高自身和群体的适合度。聚群行为(Huddling)是社会性动物在恶劣环境下为提高自身适合度进化出的一种合作适应性行为。社会性体温调节(Social thermoregulation)假说认为聚群行为可以通过减少体表面积与体积之比率以减少热量散失而节约能量。王德华研究组发表文章从生理能量学角度揭示小型哺乳动物的聚群行为可通过降低代谢产热和降低体温从而降低动物对能量的需求(Sukhchuluun et al., 2018, Frontiers in Physiology, 9:563)。该研究结果为聚群行为调节产热提供了生理学证据,对传统的社会性体温调节假说有了更深入细致的解释。


寒冷和聚群行为诱导动物肠道菌群发生改变,进而调控宿主的代谢和体温调节

宿主与肠道菌群是共同进化的。动物的生活方式可能会对其肠道菌群产生影响。进一步的研究发现,动物的聚群行为能够引起肠道菌群的丰富度和多样性升高,增加有益菌而降低有害菌的数量,提高代谢产物短链脂肪酸的含量,短链脂肪酸作为宿主的能量底物,从而降低能量需求;通过进行菌群移植也证实了肠道菌群能够介导宿主的能量和体温调节。该研究揭示了动物的聚群行为和肠道菌群调节内温动物体温和能量代谢的共同进化机制。这项研究工作以“Huddling remodels gut microbiota to reduce energy requirements in a small mammal species during cold exposure”为题于2018年6月8日在线发表于Microbiome (Zhang et al., 2018, Microbiome, 6:103)。中国科学院动物研究所农业虫害鼠害综合治理研究国家重点实验室张学英副研究员、博士研究生Gansukh Sukhchuluun和薄亭贝为共同第一作者,王德华研究员为通讯作者。该研究得到了国家自然科学基金委员会项目的资助。

原始出处:
Zhang XY, Sukhchuluun G, Bo TB, et al.Huddling remodels gut microbiota to reduce energy requirements in a small mammal species during cold exposure.Microbiome. 2018 Jun 8;6(1):103. doi: 10.1186/s40168-018-0473-9.

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    2018-09-21 zhouqu_8
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    2019-01-11 pyaili
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    2018-12-22 weiz
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1918143, encodeId=75af1918143e7, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Sep 21 11:58:00 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634165, encodeId=6b52163416514, content=<a href='/topic/show?id=4ffe11e09d8' target=_blank style='color:#2F92EE;'>#Microbiome#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11709, encryptionId=4ffe11e09d8, topicName=Microbiome)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=39c822073631, createdName=pyaili, createdTime=Fri Jan 11 00:58:00 CST 2019, time=2019-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811160, encodeId=f62c1811160c6, content=<a href='/topic/show?id=c9f9868e017' target=_blank style='color:#2F92EE;'>#节省能量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86870, encryptionId=c9f9868e017, topicName=节省能量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1c77441, createdName=weiz, createdTime=Sat Dec 22 13:58:00 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857670, encodeId=dd19185e6708b, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Wed Dec 05 08:58:00 CST 2018, time=2018-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084420, encodeId=dd8620844205b, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Aug 08 07:58:00 CST 2018, time=2018-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327028, encodeId=505832e028bb, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Jun 26 01:30:52 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392325, encodeId=a1641392325ef, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Mon Jun 25 10:58:00 CST 2018, time=2018-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=326439, encodeId=ac5c326439f6, content=学习了涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sat Jun 23 23:32:30 CST 2018, time=2018-06-23, status=1, ipAttribution=)]
    2018-08-08 xjy02
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    2018-06-26 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-06-23 虈亣靌

    学习了涨知识了!

    0

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